![](https://www.molecular-medicine-israel.co.il/wp-content/uploads/2016/07/breast-lung-cancer-metastasis-silencing-molecule-1-300x169.jpg)
On the origin of metastases: Induction of pro-metastatic states after impending cell death via ER stress, reprogramming, and a cytokine storm
Highlights •Tumor cells that survive impending death become stable pro-metastatic tumor cells, PAMEs •PAMEs display molecularly defined pro-metastatic states and form distant metastases •ER stress