Highlights Summary Drug-resistant Mycobacterium tuberculosis (Mtb) remains a major public health concern requiring complementary approaches to standard anti-tuberculous regimens. Anti-virulence molecules or compounds that enhance the activity
Highlights Summary The human pathogen Mycobacterium tuberculosis typically causes lung disease but can also disseminate to other tissues. We identified a M. tuberculosis (Mtb) outbreak presenting with unusually high rates
Highlights •Altered mitochondrial homeostasis reprograms cell death modalities •Mitochondrial ROS directs GSDMD to mitochondria following inflammasome activation •Mito-GSDMD shifts cell death from pyroptosis to necroptosis
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