Abstract Tauopathies are a heterogenous group of neurodegenerative disorders characterized by tau aggregation in the brain. In a subset of tauopathies, rare mutations in the MAPT gene,
Abstract The human cerebral cortex houses 1,000 times more neurons than the cerebral cortex of a mouse, but the possible differences in synaptic circuits between
More than 200 genes with novel and known roles in glioblastoma – the most aggressive type of brain cancer – offer promising new drug targets.
Fifteen per cent of hospital patients with severe brain injuries exhibited cognitive activity in response to commands — even though they did not react visibly.
Researchers in the UK and New Zealand have created the largest-ever database of protein expression changes associated with Alzheimer’s disease, according to a study published
Traces of the bacterium Porphyromonas gingivalis, which causes chronic gum disease, have been found in the brains of people who had Alzheimer’s disease. The result
Aggregation of the protein tau is implicated in neurodegenerative diseases in humans. It emerges that eliminating a type of damaged cell that no longer divides
Researchers at Caltech have designed a noninvasive method to control specific neural circuits in the mouse brain. The technique, published earlier this week (July 9)
EDITOR’S CHOICE IN NEUROSCIENCE The paper G.E. Doucet et al., “The role of intrinsic brain functional connectivity in vulnerability and resilience to bipolar disorder,” Am
Microglia are phagocytic cells that remove cellular debris and aggregated proteins from the brain and prune unwanted and degenerating synapses (1). When the brain is
Microglia are phagocytic cells that remove cellular debris and aggregated proteins from the brain and prune unwanted and degenerating synapses (1). When the brain is
Neural stem cells normally go with the flow of chemical guides. But with a little electrical stimulation they can be coaxed to go the other
Delivering a CRISPR/Cas9–based therapy directly to the eye via a viral vector can prevent retinal degeneration in a mouse model of retinitis pigmentosa, a team
At present, there are no disease-modifying treatments to stall the progression of Parkinson’s disease (PD). A drug in development to treat diabetes might provide a
ommon mechanisms in aging and obesity are hypothesized to increase susceptibility to neurodegeneration, however direct evidence in support of this hypothesis is lacking. We therefore
A new study led by investigators at the University of Glasgow has identified how cells protect themselves against misfolded and aggregated proteins known to be
Whether at school, in car accidents, on the sports field or the battlefield, mild traumatic brain injury (mTBI) is a common part of our lives.
Pain can be tough to take, and it’s also difficult to study: rodent models for pain do not necessarily translate to human pain conditions and
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