Highlights Summary iPSC-based drug discovery led to a phase 1/2a trial of ropinirole in ALS. 20 participants with sporadic ALS received ropinirole or placebo for
Abstract Misfolded and aggregated α-synuclein is a neuropathological hallmark of Parkinson’s disease (PD). Thus, α-synuclein aggregates are regarded as a biomarker for the development of
Significance The tendency of many cellular proteins to form protein-rich biomolecular condensates underlies the formation of subcellular compartments and has been linked to various physiological
Ligands are protein molecules that transmit signals in between or within the cells. They exert their effects by binding to cellular proteins called receptors. After
There are approximately 5.6 million people over the age of 65 living with Alzheimer’s disease in the United States. With the population aging, that number
In a mouse model of amyotrophic lateral sclerosis, animals that had ample levels the bacterium Akkermansia muciniphila in their gut microbiomes fared better than those
Sounds with a frequency of 40 hertz and lights that flicker at the same rate stimulate a pattern of brain activity known as gamma waves,
People with Parkinson’s disease have distinct chemical differences in the oil they secrete through their skin compared with healthy people, researchers report today (March 20)
Traces of the bacterium Porphyromonas gingivalis, which causes chronic gum disease, have been found in the brains of people who had Alzheimer’s disease. The result
Levels of a protein called neurofilament light chain increase in the blood and spinal fluid of some Alzheimer’s patients 16 years before they develop symptoms,
Alterations in the metabolism of the neuronal microtubule-associated protein tau are central to several neurodegenerative diseases. In these diseases, tau usually loses solubility and forms
About a third of the world’s population is chronically infected with the protozoan parasite Toxoplasma gondii. Data from the U.S. Centers for Disease Control and
About a third of the world’s population is chronically infected with the protozoan parasite Toxoplasma gondii. Data from the U.S. Centers for Disease Control and
It’s no secret that fewer than 10 percent of investigational drugs achieve regulatory approval and reach the marketplace. But the chances of success for drugs
Frequent sauna bathing can reduce the risk of dementia, according to a recent study carried out at the University of Eastern Finland. In a 20-year
Many people with Parkinson’s disease have digestive symptoms like constipation years before they have neurological symptoms, and scientists have found differences in the gut microbiome
In more than three dozen postmortem human brains, scientists have detected nanoparticles of magnetite that they suspect came from the environment. The brain produces magnetite
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