single-cell RNA-seq Archives - Israel Molecular Medicine Portal

Human embryonic genome activation initiates at the one-cell stage

Highlights •Gene expression initiates at the one-cell stage in human embryos •Expression is of low magnitude but remains elevated until the eight-cell stage •Upregulated transcripts

Cell-type modeling in spatial transcriptomics data elucidates spatially variable colocalization and communication between cell-types in mouse brain

Highlights •A neural network, STANN, models cell types in single-cell spatial transcriptomics data •Subsequent analyses reveal mouse brain architecture beyond conventional layers •Cellular colocalization and

Differential pre-malignant programs and microenvironment chart distinct paths to malignancy in human colorectal polyps

Highlights •A single-cell resolution atlas of human adenomas and serrated polyps •Serrated polyps arise from metaplasia as opposed to stem cell expansion •Cytotoxic immunity in

Molecular Medicine Israel

Tag: single-cell RNA-seq

Human embryonic genome activation initiates at the one-cell stage

Cell-type modeling in spatial transcriptomics data elucidates spatially variable colocalization and communication between cell-types in mouse brain

Differential pre-malignant programs and microenvironment chart distinct paths to malignancy in human colorectal polyps

MMiP

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