Highlights Summary The somatic mutations found in a cancer genome are imprinted by different mutational processes. Each process exhibits a characteristic mutational signature, which can
Abstract While the genomes of normal tissues undergo dynamic changes over time, little is understood about the temporal-spatial dynamics of genomes in premalignant tissues that
Abstract Somatic mutations drive the development of cancer and may contribute to ageing and other diseases1,2. Despite their importance, the difficulty of detecting mutations that
Highlights Somatic mosaicism resulting from post-zygotic mutations has been shown to contribute to many diseases including brain-related disorders, in addition to cancer. Emerging data also
Two years ago, researchers at Johns Hopkins University School of Medicine analyzed data on 31 cancer types, finding that the number of stem cell divisions
Researchers have uncovered the genomic mutations and DNA methylation patterns likely caused by tobacco smoke in 17 types of cancerous tumors. A comprehensive survey of
Somatic mosaicism—the variation of the genome between individual cells—is particularly consequential in the brain. Neuroscientists have found that small changes to the genome of even
Environmental Science and Pollution Research, 2011. DOI:10.1007/s11356-011-0481-9 Rachel Ben-Shlomo, Uri Shanas. “Genetic ecotoxicology of asbestos pollution in the house mouse Mus musculus domesticus.” Mice inhabiting
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