Abstract H-1 parvovirus (H-1PV) is a promising anticancer therapy. However, in-depth understanding of its life cycle, including the host cell factors needed for infectivity and
Highlights 16% of COVID-19 patients display an atypical low-inflammatory plasma proteome Severe COVID-19 is associated with heterogeneous plasma proteomic responses Death of virus-infected lung epithelial
Abstract Phenotype-based compound screening has advantages over target-based drug discovery, but is unscalable and lacks understanding of mechanism of drug action. A chemical-induced gene expression
Highlights •NSP16 binds mRNA recognition domains of U1/U2 snRNAs and disrupts mRNA splicing •NSP1 binds in the mRNA entry channel of the ribosome to disrupt
Interfering with cancer Many immunotherapies for cancer have emerged in recent years, but none are universally effective. One potential problem is the loss of interferon
Our ability to keep HIV under control has been revolutionized by antiretroviral therapy (ART). But ART is not a cure — the HIV genome can
A study of COVID-19 patients at two London hospitals has identified blood-based immunological changes that are linked to the disease and, in some cases, to
Scientists at Sanford Burnham Prebys Medical Discovery Institute have created a next-generation drug called Ciapavir (SBI-0953294) that is effective at reactivating dormant human immunodeficiency virus (HIV). The
On January 9 of this year, Chinese state media reported that a team of researchers led by Xu Jianguo had identified the pathogen behind a mysterious outbreak
When the Black Death arrived in London by January 1349, the city had been waiting with dread for months. Londoners had heard reports of devastation
For some COVID-19 patients, the body’s immune response may be as destructive as the virus that causes the disease. The persistent high fevers, severe respiratory
Like so many countries, Iceland, with its population of 364,000 inhabitants, has been stricken by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). From 13 January
Highlights •The spike protein of SARS-CoV-2 harbors a multibasic S1/S2 site •The host cell protease furin cleaves the SARS-CoV-2 spike protein at the S1/S2 site
The development of broad-spectrum antiviral drugs particulary in the context of emerging zoonotic infections for which specific interventions do not exist sheahnan et al. tested
A novel human coronavirus that is now named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (formerly called HCoV-19) emerged in Wuhan, China, in late 2019
Abstract One of the greatest influenza pandemic threats at this time is posed by the highly pathogenic H5N1 avian influenza viruses. To date, 61% of
Abstract One of the greatest influenza pandemic threats at this time is posed by the highly pathogenic H5N1 avian influenza viruses. To date, 61% of
The Center for Systems Science and Engineering (CSSE) at Johns Hopkins University developed a real time mapping of the corona virus. Covid-19 outbreak is now
Scientists are concerned about a new virus that has infected tens of thousands of people and killed more than 1,000. The virus, which emerged in
More than 50 research papers have been published on the new Chinese coronavirus in the past 20 days, as scientists rush to understand the pathogen
Researchers at the University of Washington have discovered a novel DNA-sensing pathway that launches an antiviral response to foreign genetic material in human cells. Triggered
A mysterious new type of pneumonia linked to a seafood market in Wuhan, China, is caused by a novel coronavirus, Chinese state media reported today
As early as the 1990s, researchers proposed that a very common type of herpes virus—then known as human herpesvirus 6 (HHV6)—could be somehow involved in
A measles outbreak in Samoa has killed 53 people since late October, including 50 children, the Samoan government reported today (December 2). Samoan Prime Minister
Nigeria, Democratic Republic of Congo, Central African Republic, and Angola have experienced nine new cases of polio caused by the live virus in oral polio
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