Mast cells link immune sensing to antigen-avoidance behaviour
Abstract The physiological functions of mast cells remain largely an enigma. In the context of barrier damage, mast cells are integrated in type 2 immunity
Abstract The physiological functions of mast cells remain largely an enigma. In the context of barrier damage, mast cells are integrated in type 2 immunity
Abstract Viruses in built environments (BEs) raise public health concerns, yet they are generally less studied than bacteria. To better understand viral dynamics in BEs,
Abstract In August 2022, a novel henipavirus (HNV) named Langya virus (LayV) was isolated from patients with severe pneumonic disease in China. This virus is
Abstract Despite no apparent defects in T cell priming and recruitment to tumors, a large subset of T cell rich tumors fail to respond to
Editor’s summary Psoriasis is a chronic inflammatory skin disease that is often accompanied by systemic complications. Using spatial transcriptomics (ST), Castillo and Sidhu et al. examined
Highlights Summary PSGL-1 (P-selectin glycoprotein-1) is a T cell-intrinsic checkpoint regulator of exhaustion with an unknown mechanism of action. Here, we show that PSGL-1 acts upstream
Abstract Bacterial bloodstream infections (BSIs) resulting in late-onset sepsis affect up to half of extremely preterm infants and have substantial morbidity and mortality. Bacterial species
Significance The ability of cells to sense and respond to mechanical forces underlies many important processes in biology, from morphogenesis to cancer metastasis. However, whether
Significance ACh-releasing choline acetyltransferase (ChAT)+ T cells promote vasodilation and regulate blood pressure in mice, but human ChAT+ T cells and the molecular mechanisms by which ChAT-expression is regulated remain
Highlights Summary HIV-1 encounters the hierarchically organized host chromatin to stably integrate and persist in anatomically distinct latent reservoirs. The contribution of genome organization in
Abstract Tumors use multiple mechanisms to actively exclude immune cells involved in antitumor immunity. Strategies to overcome these exclusion signals remain limited due to an
Dendritic cells save the day Dendritic cells are a key part of the immune system and are critical for antitumor immunity because they help to
Catching out cap snatching Some virus families hijack part of their hosts’ RNA to enable their own replication in a process called cap snatching. Before
Highlights Summary Local environmental factors influence CD8+ T cell priming in lymph nodes (LNs). Here, we sought to understand how factors unique to the tumor-draining mediastinal LN
Significance Macrophages are innate immune cells that use pattern recognition receptors such as the toll-like receptors (TLRs) to sense danger. Individual TLRs detect danger in
Abstract A highly effective malaria vaccine remains elusive despite decades of research. Plasmodium falciparum sporozoite vaccine (PfSPZ Vaccine), a metabolically active, nonreplicating, whole parasite vaccine demonstrated safety
Abstract Obesity is a state of low-grade chronic inflammation that causes multiple metabolic diseases. During obesity, signalling via cytokines of the TNF family mediate cell
Long-lived plasma cell production High-affinity antibodies that provide durable protective immunity are produced by long-lived bone marrow plasma cells that differentiate from germinal center (GC)
Abstract After viral entry and reverse transcription, HIV-1 proviruses that fail to integrate are epigenetically silenced, but the underlying mechanism has remained unclear. Using a
Time for T cell renewal Autologous hematopoietic stem cell transplantation (aHSCT) has shown great potential in subjects with multiple sclerosis (MS). Previous work showed a
Highlights •Tumor-specific T cells are necessary but not sufficient for therapeutic efficacy •IV vaccination promotes tumor regression by remodeling the TME •Systemic IFN-I following IV vaccination
Highlights •Altered mitochondrial homeostasis reprograms cell death modalities •Mitochondrial ROS directs GSDMD to mitochondria following inflammasome activation •Mito-GSDMD shifts cell death from pyroptosis to necroptosis
Abstract Protective immunity relies on the interplay of innate and adaptive immune cells with complementary and redundant functions. Innate lymphoid cells (ILCs) have recently emerged
Highlights • L108F in MPXV DNA polymerase emerged in the 2022 outbreak.• L108F can enhance DNA binding affinity, processivity and drug sensitivity of F8L.• Mutation
Highlights •Six human mAbs target five distinct sites on EBV gH/gL •Some of these antigenic sites match sites of vulnerability on other herpesviruses •Each mAb
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