Abstract We study the collapse and expansion of a cavitation bubble in a deformable porous medium. We develop a continuum-scale model that couples compressible fluid
Abstract Microglia are emerging as key drivers of neurological diseases. However, we lack a systematic understanding of the underlying mechanisms. Here, we present a screening
Abstract Advances in 3D neuronal cultures, such as brain spheroids and organoids, are allowing unprecedented in vitro access to some of the molecular, cellular and
Abstract We describe in vivo follow-up PET imaging and postmortem findings from an autosomal dominant Alzheimer’s disease (ADAD) PSEN1 E280A carrier who was also homozygous for the APOE3 Christchurch
Highlights •VNS paired with success enhances skilled motor learning in healthy animals •Enhanced motor performance is due to accelerated consolidation of an expert motor plan
Halting astrocytes at the GAT3 Uncontrolled inflammation in the brain after an injury has been shown to contribute to increased seizure risk and cognitive impairments.
A growing body of literature ties the gut microbiome to symptoms of depression in a seemingly circular relationship where each affects the other. However, many of the studies
Highlights •NPC proliferation defects are common in idiopathic and 16p11.2 CNV-deletion ASD •All macrocephalic I-ASD and 16pDel individuals have hyperproliferative NPCs •NPC proliferative responses to
Abstract The ability of immune-modulating biologics to prevent and reverse pathology has transformed recent clinical practice. Full utility in the neuroinflammation space, however, requires identification
bstract Genetic variants in YWHAZ contribute to psychiatric disorders such as autism spectrum disorder and schizophrenia, and have been related to an impaired neurodevelopment in humans and
Highlights •We made a light-weight 2-photon miniscope for calcium imaging in freely moving mice •Stable high-quality imaging was observed during a wide spectrum of behaviors
Targeting microglia with niacin Microglia have been shown to contribute in Alzheimer’s disease (AD) pathophysiology. However, the role of these cells remains to be completely
Abstract Progressive degeneration of dopaminergic (DA) neurons in the substantia nigra is a hallmark of Parkinson’s disease (PD). Dysregulation of developmental transcription factors is implicated
Highlights •PolyP is enriched in human and mouse ALS/FTD astrocytes in vitro and in vivo •Excessive polyP released by ALS/FTD astrocytes is toxic to primary MNs •In vitro studies indicate that polyP
Significance Multiple sclerosis (MS) is the most prevalent autoimmune disease of the central nervous system (CNS), leading to irreversible deficits in young adults. Its pathophysiology
Abstract The hippocampus is critical to the temporal organization of our experiences. Although this fundamental capacity is conserved across modalities and species, its underlying neuronal
Abstract Despite the importance of the cerebrovasculature in maintaining normal brain physiology and in understanding neurodegeneration and CNS drug delivery1, human cerebrovascular cells remain poorly
Abstract Mutations in the putative glutamatergic synapse scaffolding protein SAP97 are associated with the development of schizophrenia in humans. However, the role of SAP97 in
Abstract The epidermal growth factor receptor (EGFR) is frequently mutated in human cancer1,2, and is an important therapeutic target. EGFR inhibitors have been successful in
Although severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is considered a respiratory pathogen, myriad neurologic complications—including confusion, stroke, and neuromuscular disorders—manifest during acute COVID-19. Furthermore,
Abstract Guided by gut sensory cues, humans and animals prefer nutritive sugars over non-caloric sweeteners, but how the gut steers such preferences remains unknown. In
Significance Rhythmic brain activity is a signature of information processing. Common inhibitory cells, spike-frequency adapting interneurons, are typically thought to only participate in low-frequency rhythms
Abstract Background Research on the electroencephalographic (EEG) signatures of attention-deficit hyperactivity disorder (ADHD) has historically concentrated on its frequency spectrum or event-related evoked potentials. In
Abstract Early detection and intervention in schizophrenia requires mechanism-based biomarkers that capture neural circuitry dysfunction, allowing better patient stratification, monitoring of disease progression and treatment.
Highlights • Dyskinesia is a debilitating side effect of levodopa, the mainstay pharmacotherapy for Parkinson’s disease.• Attenuating dyskinesia has been a significant challenge in the
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