Abstract Whereas oncogenes can potentially be inhibited with small molecules, the loss of tumour suppressors is more common and is problematic because the tumour-suppressor proteins
Abstract Nanomaterials offer unique opportunities to engineer immunomodulatory activity. In this work, we report the Toll-like receptor agonist activity of a nanoscale adjuvant zeolitic imidazolate
Abstract Malaria is a major cause of illness and death worldwide. Rapid diagnostic tests are the most widely used tool for detecting malaria infection, however, they only
Highlights Summary Children diagnosed with autism spectrum disorder (ASD) commonly present with sensory hypersensitivity or abnormally strong reactions to sensory stimuli. Such hypersensitivity can be
Abstract With the emergence of Alzheimer’s disease (AD) disease-modifying therapies, identifying patients who could benefit from these treatments becomes critical. We evaluated whether a precise
Abstract Psychosis occurs inside the brain, but may have external manifestations (peripheral molecular biomarkers, behaviors) that can be objectively and quantitatively measured. Blood biomarkers that
Abstract Functionalizing cotton to induce biological activity is a viable approach for developing wound dressing. This study explores the development of cotton-based wound dressing through coating
Abstract Senescent cells, which accumulate in organisms over time, contribute to age-related tissue decline. Genetic ablation of senescent cells can ameliorate various age-related pathologies, including
Abstract The discovery of novel structural classes of antibiotics is urgently needed to address the ongoing antibiotic resistance crisis1,2,3,4,5,6,7,8,9. Deep learning approaches have aided in
Abstract Apical extracellular matrices (aECMs) are complex extracellular compartments that form important interfaces between animals and their environment. In the adult C. elegans cuticle, layers are connected
Abstract The structures and functions of organelles in cells depend on each other but have not been systematically explored. We established stable knockout cell lines
The early days of stem cell culture set the stage for organoid research by spotlighting highly proliferative tissues such as the small intestine, stomach, and
Editor’s summary Most methods for three-dimensional (3D) printing of polymers use focused light to control the formation of volume units (voxels). Kuang et al. developed a
Editor’s summary Idiopathic pulmonary fibrosis is characterized by failed lung regeneration and fibrosis development, ultimately leading to respiratory failure and death. Here, Lang and colleagues
Abstract We recently reported that multiple sclerosis (MS) plasma contains IgG aggregates and induces complement-dependent neuronal cytotoxicity (Zhou et al., 2023). Using ELISA, we report herein that plasma
Summary Inspired by nature, modern nanotechnology has enabled the bottom-up construction of molecular machines and nanorobots using two different biomolecular building blocks, DNAs or peptides. As an
Highlights Summary Heterologous organ transplantation is an effective way of replacing organ function but is limited by severe organ shortage. Although generating human organs in
Abstract Brain infiltration of peripheral immune cells and their interactions with brain-resident cells may contribute to Alzheimer’s disease (AD) pathology. To examine these interactions, in
Abstract HIV-1 infection depends on the integration of viral DNA into host chromatin. Integration is mediated by the viral enzyme integrase and is blocked by
Abstract Bacteriophages operate via pathogen-specific mechanisms of action distinct from conventional, broad-spectrum antibiotics and are emerging as promising alternative antimicrobials. However, phage-mediated killing is often
Abstract Tau protein fibrillization is implicated in the pathogenesis of several neurodegenerative diseases collectively known as Tauopathies. For decades, investigating Tau fibrillization in vitro has
Abstract Huntington’s disease is a neurodegenerative disorder caused by a CAG expansion in the first exon of the HTT gene, resulting in an extended polyglutamine (poly-Q) tract
Summary Background Emerging evidence shows that α-synuclein seed amplification assays (SAAs) have the potential to differentiate people with Parkinson’s disease from healthy controls. We used
Abstract Medulloblastoma is the most common malignant paediatric brain tumour, with ~30% mediated by Sonic hedgehog signalling. Vismodegib-mediated inhibition of the Sonic hedgehog effector Smoothened
Abstract Neural regeneration is extremely difficult to achieve. In traumatic brain injuries, the loss of brain parenchyma volume hinders neural regeneration. In this study, neuronal
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