Cells respond to metabolic fluctuations by adjusting the speed of DNA replication as a safeguard for genome stability. Somyajit et al. elucidate the cellular mechanisms that align replication fork dynamics with metabolic pathways (see the predictive by Gomez-Gonzalez and Aguilera). The evaluation of reactive oxygen species (ROS) levels under metabolic stress disociates a replication accelerator from the replisome and leads to replication slowdown.
