Molecular Medicine Israel

New Method for Reprogramming Cells

An external stressor, such as low pH or a mechanical squeeze, can send differentiated mouse cells back to a pluripotent state

Current approaches for turning differentiated adult cells back into a stem–cell-like state involve messing with the nucleus in one way or another—either swapping out nuclear contents, a process called nuclear transfer, or inducing the expression of pluripotency genes. In two papers published in Nature (1, 2), researchers have developed an entirely different technique, this one based on exposure to environmental stimuli, including mechanical stress or a low pH.

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