Significance Amplification of MYC and mutation of p53 are frequently found in human cancers, yet directly targeting it has proven difficult. Thus, exploring alternative methods to hinder
Abstract Background The cerebral cortex is organised hierarchically along an axis that spans unimodal sensorimotor to transmodal association areas. This hierarchy is often characterized using
Abstract Despite the prominent role of the K-Ras protein in many different types of human cancer, major gaps in atomic-level information severely limit our understanding
Editor’s summary Cancer survivors often experience cognitive impairments after chemotherapy, and these side effects are commonly known as chemobrain. Here, Liu and colleagues treated breast
Significance Functional MRI (fMRI) has proven valuable at mapping cortical activity in the brain. However, many fMRI studies may be underestimating the extent of activation
Highlights Summary Single-cell analysis in living humans is essential for understanding disease mechanisms, but it is impractical in non-regenerative organs, such as the eye and
Highlights Summary Multiple tyrosine kinase inhibitors (TKIs) are often developed for the same indication. However, their relative overall efficacy is frequently incompletely understood and they
Abstract Raynaud’s phenomenon (RP) is a common vasospastic disorder that causes severe pain and ulcers, but despite its high reported heritability, no causal genes have
Some people in hospital die not from the illness or accident that got them admitted but from germs they catch once there. In the United
Abstract The application of RNA interference (RNAi) to mammalian cells has provided the means to perform phenotypic screens to determine the functions of genes. Although
Abstract HER2 mutations drive the growth of a subset of breast cancers and are targeted with HER2 tyrosine kinase inhibitors (TKI) such as neratinib. However, acquired
Abstract Insulin resistance is the primary pathophysiology underlying metabolic syndrome and type 2 diabetes1,2. Previous metagenomic studies have described the characteristics of gut microbiota and
Abstract Human female infertility, 20% of which is idiopathic, is a public health problem for which better diagnostics and therapeutics are needed. A novel cause
Abstract Inflammation is a complex physiological process triggered in response to harmful stimuli1. It involves cells of the immune system capable of clearing sources of
Abstract Cell-based therapeutics are an emerging modality with the potential to treat many currently intractable diseases through uniquely powerful modes of action. Despite notable recent
Abstract Coronavirus spike proteins mediate receptor binding and membrane fusion, making them prime targets for neutralizing antibodies. In the cases of severe acute respiratory syndrome
Editor’s summary The current opioid crisis emphasizes the need for nonaddictive pain treatments. Here Perez-Sanchez and colleagues evaluated whether direct inhibition of pain-related hyperactivity in
Abstract A well-functioning placenta is essential for fetal and maternal health throughout pregnancy. Using placental weight as a proxy for placental growth, we report genome-wide
Summary Inspired by nature, modern nanotechnology has enabled the bottom-up construction of molecular machines and nanorobots using two different biomolecular building blocks, DNAs or peptides. As an
Significance Streptococcus pneumoniae is an important bacterial pathogen responsible for many serious infections worldwide. Infections are often treated with penicillin antibiotics. This provides a selection pressure
Editor’s summary Healthcare-associated infections are a leading threat to patient safety during hospital stays, and strategies to prevent such infections are lacking. Here, Yan et al.
Abstract BACKGROUND In treatment-resistant depression, commonly defined as a lack of response to two or more consecutive treatments during the current depressive episode, the percentage
Editor’s summary During pregnancy, some exchange of cells occurs between the mother and the offspring, with fetal cells persisting in small quantities in the mother
Abstract DNA base editors use deaminases fused to a programmable DNA-binding protein for targeted nucleotide conversion. However, the most widely used TadA deaminases lack post-translational
Abstract Increasing levels of artemisinin and partner drug resistance threaten malaria control and elimination globally. Triple artemisinin-based combination therapies (TACTs) which combine artemisinin derivatives with
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