Molecular Medicine Israel

A role for CXCR2 signalling in cartilage homeostasis.

ELR (glutamic acid-leucine-arginine motif positive) CXC chemokines, which bind heparin and signal through the receptors CXCR1 and CXCR2 in humans and CXCR2 in mice, have a well-established role in the pathogenesis of arthritis, attributed to their capacity to attract inflammatory cells. New research, however, points to an unexpected role for C…

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