Abstract The obesity epidemic continues to worsen worldwide, driving metabolic and chronic inflammatory diseases. Thiazolidinediones, such as rosiglitazone (Rosi), are PPARγ agonists that promote ‘M2-like’
Abstract Bacteriophages are ubiquitous viral predators that have primarily been studied using fast-growing laboratory cultures of their bacterial hosts. However, microbial life in nature is
Highlights Summary In humans, balanced invasion of trophoblast cells into the uterine mucosa, the decidua, is critical for successful pregnancy. Evidence suggests that this process is
Editor’s summary Spontaneous labor involves complex communication between maternal and fetal cells, but our understanding of this cross-talk is limited. Here, Garcia-Flores and colleagues generated
Editor’s summary Mutations in leucine-rich repeat kinase 2 (LRRK2) are implicated in the development of Parkinson’s disease, so this enzyme is a target for therapeutics
Editor’s summary Pregnant women infected with Zika virus (ZIKV) can vertically transmit virus to fetuses, which has been linked to congenital ZIKV syndrome. Understanding how
Highlights Summary Head and neck squamous cell carcinomas (HNSCCs) have high mortality and significant treatment-related morbidity. It is vital to discover effective, minimally invasive therapies
Significance The obligate intracellular bacterial pathogen, Coxiella burnetii, is the causative agent of the zoonotic infection termed Q fever. Agricultural outbreaks are an increasingly significant economic
Abstract Tissues within an organism and even cell types within a tissue can age with different velocities. However, it is unclear whether cells of one
Abstract There is a growing appreciation that the direct interaction between bacteriophages and the mammalian host can facilitate diverse and unexplored symbioses. Yet the impact
Abstract Inflammation is a complex physiological process triggered in response to harmful stimuli1. It involves cells of the immune system capable of clearing sources of
Editor’s summary During pregnancy, some exchange of cells occurs between the mother and the offspring, with fetal cells persisting in small quantities in the mother
Highlights Summary The ability to map trafficking for thousands of endogenous proteins at once in living cells would reveal biology currently invisible to both microscopy
Editor’s summary Cell layers can slip, slide, and fold in among one another during development to generate the complex forms of the biological world. Studying
Highlights Summary The pentameric FERRY Rab5 effector complex is a molecular link between mRNA and early endosomes in mRNA intracellular distribution. Here, we determine the
Highlights Summary Although the role of RNA binding proteins (RBPs) in extracellular RNA (exRNA) biology is well established, their exRNA cargo and distribution across biofluids are largely
Abstract Vision is initiated by the rhodopsin family of light-sensitive G protein-coupled receptors (GPCRs)1. A photon is absorbed by the 11-cis retinal chromophore of rhodopsin, which
Highlights • Structure of PCSK9/CHRD and an inhibitory nanobody that prevents LDLR degradation.• Binding of CAP1 to PCSK9 enhances its activity and abrogates nanobody inhibition.•
Abstract The early stages of the virus–cell interaction have long evaded observation by existing microscopy methods due to the rapid diffusion of virions in the
Making a mature cell skeleton Actin molecules are critical components of the cytoskeleton, controlling processes such as cellular organization, organelle trafficking, and force generation. Actin
Abstract Extracellular sulfatase-2 (Sulf-2) influences receptor–ligand binding and subsequent signaling by chemokines and growth factors, yet Sulf-2 remains unexplored in inflammatory cytokine signaling in the
Highlights •Plasma membrane ruffles are a mechanical immune signal caused by bacterial invasion •The mechanosensor PIEZO1 detects infection-induced ruffles and mediates Ca2+ influx •PIEZO1 activation triggers
Abstract Oocytes form before birth and remain viable for several decades before fertilization1. Although poor oocyte quality accounts for most female fertility problems, little is
Abstract Single pass cell surface receptors regulate cellular processes by transmitting ligand-encoded signals across the plasma membrane via changes to their extracellular and intracellular conformations.
Abstract Gasdermins (GSDMs) are a family of pore-forming effectors that permeabilize the cell membrane during the cell death program pyroptosis1. GSDMs are activated by proteolytic
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