Targeting upstream phosphatidylinositol-3-kinases (PI3Ks) in the PI3K/Akt/mTOR pathway appears to be a promising therapy in solid cancers; however, first early clinical trials with PI3K inhibitors
As many as 8 percent of pregnant women develop a condition known as preeclampsia, a spike in blood pressure characterized by the reduced formation of
Abstract Macrophages have diverse functions in immunity as well as development and homeostasis. Here we identify a function for these cells in long distance communication
Adenosine triphosphate (ATP) is the canonical energy carrier that powers cellular machines, drives metabolic reactions, and serves as a precursor to nucleic acids. On page
Type I diabetes had rendered a 43-year-old woman dependent on insulin, until doctors restored her body’s ability to produce the hormone with engineered islet cells
Detailed maps of the immune cells that surround tumours could suggest fresh therapeutic targets, point out biological markers that can be used to select the
Highlights •PD-L1 is primarily regulated by interferon gamma signaling in melanoma cells •PD-L2 is regulated by both interferon beta and gamma signaling •Regulation of PD-1
Some pathogens block generation of reactive oxygen species to evade neutrophil killing, but how that is accomplished is poorly understood. In this issue of Cell
During senescence, cells remain in a state of growth arrest. Accumulation of similar nonfunctional cells has been linked to chronic inflammatory diseases and degenerative disorders.
Give us our daily protein Protein is an essential component of our food, and protein intake thus must be actively regulated. Liu et al. identified
Highlights GRK5-β2AR binding is enhanced by receptor and kinase ligands and acidic lipids GRK5 binding to the β2AR involves a multi-site interaction Receptor binding triggers
In this issue of Cell, Baar et al. show how FOXO4 protects senescent cell viability by keeping p53 sequestered in nuclear bodies, preventing it from inducing
During infection, malaria parasites must invade erythrocytes. Erythrocytes are flexible cells that can easily deform to make it through the tight spaces of the vasculature,
Highlights Primary human testicular cells form organoids regardless of scaffold support The testis-specific cytoarchitecture was not restored in testicular organoids Active niche cells and spermatogonia
The role of RAS dimerization in tumor biology is an emerging area of preclinical cancer research. Characterization of a RAS monobody indicates that dimer formation
ukaryotic cells store their DNA in the nucleus, cordoned off from the cytoplasm by the nuclear envelope. Made up of two lipid bilayers called the
It has been 8 years since an astonishing observation persuaded many scientists that the misfolded protein implicated in Parkinson’s disease spreads from brain cell to
It has been 8 years since an astonishing observation persuaded many scientists that the misfolded protein implicated in Parkinson’s disease spreads from brain cell to
Highlights •GOLM1 is identified as a leading gene relating to HCC metastasis •GOLM1 is correlated to early metastatic recurrence and poor survival of HCC patients
Increasing the levels of therapeutic proteins in vivo remains challenging. Antisense oligonucleotides (ASOs) are often used to downregulate gene expression1 or to modify RNA splicing2,
Chromatin structure stabilizes and compacts the genome to package it within the nucleus. This structure also serves as a dynamic regulator of gene expression, silencing
The non-receptor protein tyrosine phosphatase SHP2, encoded by PTPN11, has an important role in signal transduction downstream of growth factor receptor signalling and was the
Working out is good for the brain. Now, a team of scientists from the U.S. and Germany has a clearer idea why. A protein called
Multiple sclerosis (MS) is an autoimmune disorder characterized by T cell-mediated demyelination and neurodegeneration in the CNS (Friese and Fugger, 2005, Pender and Greer, 2007, Sospedra
Researchers at the US National Cancer Institute (NCI) have successfully visualized the structures of enzymes at near-atomic resolutions previously not considered possible, using cryo-electron microscopy
Created by ePubSystems. Contact Us for similar site for your university or institute.