An international team of researchers has successfully reprogrammed human α cells into insulin-producing β cells, according to a study published yesterday (February 13) in Nature.
In 2007, Ho Man “Holly” Tang took a break from her undergraduate biology studies at Iowa State University to join her older brother, Ho Lam
Highlights • Single-cell RNA-seq stratifies patients with similar clinical presentation • A pseudotemporal profile aligns single cells along a control to disease axis • HDAC4
A major cause of type 2 diabetes is obesity, in which fat cells expand rapidly, in both size and number, and their oxygen demand outstrips
Cellular metabolism is an interconnected network of chemical reactions, each step catalyzed by dedicated enzymes. Inhibition or intentional removal of an enzyme should grind the
CD95/Fas ligand binds to the death receptor CD95 to induce apoptosis in sensitive cells. We previously reported that CD95L mRNA is enriched in sequences that,
Setting liver regeneration free The liver is an excellent model of organ regeneration; however, regeneration may fail in a normal liver after acute severe injury
Cytokines and interferons initiate intracellular signaling via receptor dimerization and activation of Janus kinases (JAKs). How JAKs structurally respond to changes in receptor conformation induced
Highlights •SRPKIN-1 is the first irreversible inhibitor for SRPK1/2 kinase •SRPKIN-1 is the first kinase inhibitor that targets a tyrosine residue covalently •SRPKIN-1 inhibits phosphorylation
When cells migrate, they normally do so by adopting a characteristic polarized morphology with the nucleus seemingly pushing from behind. The internal cytoskeleton forms well-organized
Highlights •In contrast to animals, how bacteria behave during combat is poorly understood •Escherichia coli use diverse strategies when attacking opponents with colicin toxins •Cells
A new paper claims that there may be no such thing as a maximum life span for naked mole rats. As these burrowing, sausage-shaped rodents
Abstract The recent advent of methods for high-throughput single-cell molecular profiling has catalyzed a growing sense in the scientific community that the time is ripe
Accumulating evidence indicates that dysregulation of microbiota-host interactions associates with various diseases, including inflammatory bowel diseases (IBDs), colorectal cancer, diabetes, and liver cirrhosis (1). Recently,
Aminoglycoside antibiotics bind to bacterial ribosomes and inhibit protein synthesis. Eukaryotic ribosomes, in contrast, are not strongly inhibited by these molecules but show errors such
When cells in our body die, it is important that they are cleared from the system so that they do not cause inflammation or further
G-protein-coupled receptors mediate the biological effects of many hormones and neurotransmitters and are important pharmacological targets1. They transmit their signals to the cell interior by
Highlights •Different EGFR ligands stabilize receptor dimers with distinct structures •Epiregulin and epigen induce weaker and more short-lived EGFR dimers than EGF •Weakened dimerization causes
The p53 transcription factor is a critical barrier to pancreatic cancer progression. To unravel mechanisms of p53-mediated tumor suppression, which have remained elusive, we analyzed
Abstract Transient increases in mitochondrially-derived reactive oxygen species (ROS) activate an adaptive stress response to promote longevity. Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases produce ROS
NA comes in many shapes and sizes. Over the past few decades, researchers have characterized at least two dozen different RNA varieties beyond the textbook
In this issue of JEM, Marciniak et al. (https://doi.org/10.1084/jem.20161731) identify a putative novel function of tau protein as a regulator of insulin signaling in the
Abstract Activating mutations cartier love bracelet involving hermes belt the PI3K pathway occur frequently in human cancers. However, PI3K inhibitors primarily induce cell cycle arrest,
Around half of all organ transplants in humans are rejected by the cartier jewelry replica recipient’s immune system within 10 to 12 years. Scientists studying
G-protein-coupled receptor (GPCR)-mediated signal transduction is central to human physiology and disease intervention, yet the molecular mechanisms responsible for ligand-dependent signalling responses remain poorly understood.
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