Abstract Gasdermins (GSDMs) are a family of pore-forming effectors that permeabilize the cell membrane during the cell death program pyroptosis1. GSDMs are activated by proteolytic
Acne in action Adipogenesis plays a key role during deep tissue infection with Staphylococcus aureus, but the contribution of this process in acne caused by Cutibacterium acnes is
The making and removal of a leader When epithelia are injured, the remaining cells repair the epithelial sheet by migrating into and closing the open
Highlights •T. gondii bradyzoite and tachyzoite-infected cells show distinct transcriptional patterns •Protein export in bradyzoites is important for host transcriptional changes •The effector IST is exported in
Highlights •A neural network, STANN, models cell types in single-cell spatial transcriptomics data •Subsequent analyses reveal mouse brain architecture beyond conventional layers •Cellular colocalization and
Abstract Pro-inflammatory T cells in the central nervous system (CNS) are causally associated with multiple demyelinating and neurodegenerative diseases1,2,3,4,5,6, but the pathways that control these
Timing is said to be the secret to comedy and to success in life, but it could also be one of the secrets to a
Making ribosomes in human cells The assembly of the human ribosome requires a vast number of assembly factors that first form a giant precursor of
Highlights •Severe NaV1.2 deficiency results in enhanced neuronal excitability in adult mice •Increased excitability is accompanied by a higher voltage threshold in striatal MSNs •Hyperexcitability
Several RNA viruses can establish life-long persistent infection in mammalian hosts, but the fate of individual virus-infected cells remains undefined. Here we used Cre recombinase–encoding
More VEGF, more life span and health span Advanced aging is celebrated but its ill effects of deterioration at the cell, tissue, and organ levels
Highlights Intestinal prematurity is characterized by the lack of efficient IL-22 production rIL-22 enhances the regeneration and integrity of intestinal epithelium during NEC rIL-22-driven antimicrobial
Aging sees many physiological changes. Studies are revealing the dynamics of the cells and molecular factors that contribute to the aging process. For example, chronological
Highlights •A reverse genetics approach determines genes required for normal cell division •Normal cell division requires genes of known and unknown function •JCVI-syn3A offers a
Enhancing EGFR to offset osteoarthritis Cartilage degeneration in osteoarthritis causes pain and limits mobility. Wei et al. investigated epidermal growth factor receptor (EGFR) signaling as a potential
Abstract Chaperones are essential for assisting protein folding and for transferring poorly soluble proteins to their functional locations within cells. Hydrophobic interactions drive promiscuous chaperone-client
Abstract Cells rely upon producing enzymes at precise rates and stoichiometry for maximizing functionalities. The reasons for this optimal control are unknown, primarily because of
Highlights •NSP16 binds mRNA recognition domains of U1/U2 snRNAs and disrupts mRNA splicing •NSP1 binds in the mRNA entry channel of the ribosome to disrupt
Highlights •Systematic analysis reveals G protein selectivity of all canonical RGS proteins •RGS proteins rely on selectivity bar codes for selective G protein recognition •Transplantation
ABSTRACT An outbreak of the novel coronavirus SARS-CoV-2, the causative agent of COVID-19 respiratory disease, has infected over 290,000 people since the end of 2019,
Abstract Caspase-dependent apoptosis accounts for approximately 90% of homeostatic cell turnover in the body1, and regulates inflammation, cell proliferation, and tissue regeneration2,3,4. How apoptotic cells
Multicellular life requires individual cells to cooperate in a way that benefits the organism. Cells that are uncooperative because they are damaged or dysfunctional, and
In one of the University of Sheffield’s physics labs, a few hundred photosynthetic bacteria were nestled between two mirrors positioned less than a micrometer apart.
Exposure of cells to acidic conditions outside the cell activates chloride-conducting channels that influence physiological and pathological processes. Yang et al. used an unbiased RNA
HeLa cells have now been cultured for nearly 70 years in many labs across the world, and were long considered to be an infinite supply
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