The ice plant thrives in salty ocean-side mist. Barkla et al. used proteomics to identify proteins in these halophytes that are critical to the defense
The White House today (May 13) announced the launch of a National Microbiome Initiative to support research on the microorganisms that live in or on
RNA consists of a phosphate backbone, sugar, and four bases (A, U, C, G), and has long seemed a promising candidate for early life’s precursor,
Scientists at the Gladstone Institutes have discovered how the major genetic risk factor for Alzheimer’s disease causes memory impairment. A specific type of brain activity
Scientists at the Gladstone Institutes have discovered how the major genetic risk factor for Alzheimer’s disease causes memory impairment. A specific type of brain activity
A newly discovered pathway leading to neurodegeneration in Alzheimer’s disease (AD) may unlock the door to new approaches for treating the disease. The findings, published
A newly discovered pathway leading to neurodegeneration in Alzheimer’s disease (AD) may unlock the door to new approaches for treating the disease. The findings, published
Researchers at the Vollum Institute in Portland, Oregon, have resolved the crystal structures of the human serotonin transporter (SERT) bound to two different antidepressant drugs.
Apoptosis, necrosis, and pyroptosis The routes to cell death are many, and distinguishing which path a particular cell may have taken remains a challenge. Wallach
A team of researchers from Israel and the U.S. has developed the first lines of human, haploid embryonic stems cells, according to a study published
Many tissues harbor a reservoir of stem cells that remains quiescent but can be activated as needed for growth and repair. How cells enter, maintain,
Androgen deprivation therapy (ADT) has been the standard of care for management of metastatic prostate cancer for more than 70 years. Its use in locally
The RNA-guided endonuclease Cas9 is a versatile genome-editing tool with a broad range of applications from therapeutics to functional annotation of genes. Cas9 creates double-strand
The skin is home to millions of commensal bacteria and immune cells. Yet how the skin microbiome is established in particular, why the immune system
Jeanne Calment has nothing on Creme Puff, the cat. The oldest living human made it to the ripe age of 122 not bad for a
Obesogens, such as the extensively studied fungicide tributyltin (TBT), can act in a variety of ways to promote fat storage and adipose tissue production, often
Doctors wrote 259 million opioid prescriptions for Americans in 2012, enough to medicate every adult in the country. Drug overdoses are eclipsing car crashes as a leading cause of accidental death for
Oncogenic activation of BRAF fuels cancer growth by constitutively promoting RAS-independent mitogen-activated protein kinase (MAPK) pathway signalling1. Accordingly, RAF inhibitors have brought substantially improved personalized
Between October 2013 and July 2014, six healthy, middle-aged men reported to Temple University Hospital in north Philadelphia. For seven days, researchers confined each subject
A commonly prescribed antidepressant exerts epigenetic effects that may provide a useful biomarker of whether the drug works in patients. A team led by researchers
D2 dopamine receptors are targeted by antipsychotic agents to regulate behavior. Likhite et al. found putative arginine methylation motifs in some human G protein–coupled receptors
Cells read their environment to trigger an appropriate response for tissue homeostasis. Work now shows that intestinal progenitor cells use the RNA-binding protein Lin-28 to
We live in a world flooded with light 24 hours a day. Before our recent harnessing of electricity, light was a reliable indicator of seasonal
A process called the epithelial-to-mesenchymal transition allows cancer cells to invade nearby tissue and metastasize. Katz et al.investigated the molecular underpinnings of this process and
Exosomes are tiny vesicles released from cells that carry proteins, lipids, and nucleic acids: cargo that can affect the biology of recipient cells. In a
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