There is a mountain of evidence to support that a high body mass index (BMI) and obesity negatively impact cancers, diabetes, cardiovascular, and other diseases.
Messenger RNA has been viewed as a potential therapy for several diseases for many years. However, the biggest obstacle to this approach so far has
In carcinomas, cancer cells often win the loyalty of neighboring cells, stromal cells, that should know better. Rather than stand aside and let the immune
Highlights • Many independent studies have demonstrated a key role for GPCRs in cancer. • GPCRs are the most successful pharmaceutical target class yet only
p53 is an important tumor-suppressor protein that is mutated in more than 50% of cancers. Strategies for restoring normal p53 function are complicated by the
Studying scorpions comes with its share of danger, as biologist Bryan Fry of the University of Queensland knows all too well. On a 2009 trip
Cancer chemotherapeutic agents are developed and approved largely on the back of studies that demonstrate an average efficacy and safety across possibly thousands of patients.
Highlights Primary human testicular cells form organoids regardless of scaffold support The testis-specific cytoarchitecture was not restored in testicular organoids Active niche cells and spermatogonia
Cannabinoid receptor 1 (CB1) represents a promising therapeutic target for a wide range of disorders. However, the molecular details that define the binding modes of
Neutrophil extracellular traps (NETs), made of processed chromatin bound to cytotoxic enzymes, are released by neutrophils into the extracellular space to control microbial infections. However,
Kidney cancer has frustrated the best efforts of clinicians. The disease is notoriously resistant to chemotherapy, and is often caught only after it has metastasized.
Natural products have historically been of crucial importance in the identification and development of antibacterial agents. Interest in these systems has waned in recent years,
Oncogenic activation of BRAF fuels cancer growth by constitutively promoting RAS-independent mitogen-activated protein kinase (MAPK) pathway signalling1. Accordingly, RAF inhibitors have brought substantially improved personalized
The momentum of a cancer’s attack can be used against the cancer, say scientists who practice a form of molecular judo. Instead of directly blocking
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