Highlights • ZGA genes and transposable elements are expressed in 8CLCs but not in naive stem cells• DUX4 overexpression and spliceosome inhibition induce ZGA-like transcription•
A single type of mouse stem cell can generate a structure in culture capable of self-organizing to generate both embryonic cells and those that are
There should be a global moratorium on editing heritable DNA from humans, scientists and bioethicists from seven countries write today (March 13) in a Nature
Over the past five years, various studies have shown that mouse and human stem cells can spontaneously organize in a dish into 3D structures that
For the first time, researchers have used the DNA from two mouse mothers to create healthy pups, some of which matured and had their own
Using CRISPR, researchers have crafted a technique to study mammalian development in exceptional detail, according to a report published in Science yesterday (August 9). “This
Researchers have used three types of stem cells to create a mouse embryo in a dish, according to research published in Nature Cell Biology yesterday
In the mid-1950s, Sam Clark Jr. of the School of Medicine at Washington University in St. Louis looked through his electron microscope at newborn-mouse kidneys
Last May, to much fanfare, an international group of researchers published two papers describing a new in vitro system that had maintained human embryos in
A team of Chinese researchers who were the first to report having applied CRISPR to human embryos have done it again—this time upgrading their technique
Scientists have used the gene-editing CRISPR-Cas9 system to suppress the gene encoding the protein OCT4 in experiments with human embryos. According to the results, published
Last week, word got out that a team of scientists had edited viable human embryos for the first time in the United States. Details of
Two teams have developed innovative new applications of the popular genome-editing method CRISPR. One of the groups has used it to mark and trace cells
Preserving the distinction between research purposes and clinical applications, the Human Fertilisation and Embryology Authority (HFEA), a U.K. regulatory body, has approved the use of
In the wake of the first ever report that scientists have edited the genomes of human embryos, experts cannot agree on whether the work was
Research that uses powerful gene-editing techniques on human embryos needs to be restricted, scientists agree but they are split over why. Some say that if
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