Significance Although symptomatic medications are available, many temporal lobe epilepsy (TLE) patients remain unresponsive to treatment and new drug targets are needed. Connexin-based gap junctions
Curbing neonatal seizures with KCC2 Neonatal seizures are often associated with cerebral ischemia, resistance to antiseizure drugs, and reduced abundance of KCC2, a K+/Cl− cotransporter that
Highlights •Severe NaV1.2 deficiency results in enhanced neuronal excitability in adult mice •Increased excitability is accompanied by a higher voltage threshold in striatal MSNs •Hyperexcitability
Highlights •CaMKIIα phosphorylates GluN2A at Ser-1459 in response to glycine stimulation •CaMKIIα and SNX27 are required for the glycine-induced increase in surface GluN2A •GluN2A Ser-1459
Highlights •Superficial CA1 pyramidal neurons are overactive in epileptic rodents •Neurodegeneration-related gene signatures progress radially in the epileptic CA1 •Larger vulnerability of superficial CA1 pyramidal
As a treatment for severe epilepsy, some children have half their brain surgically removed. Although these patients may end up with sensory, movement, or language
Delicate lines dance across a screen mounted on the wall of the operating room. Their peaks and valleys become pronounced, suddenly flatten into a straight
When people listened to questions from a predetermined set and spoke a response from a group of answer options, a computer program could correctly predict
An international team of researchers, including scientists at the Royal College of Surgeons in Ireland (RCSI), has discovered 11 new genes associated with epilepsy. The
Highlights • Changes in the gut microbiota are required for the anti-seizure effects of the KD • Specific KD-associated bacteria mediate and confer the anti-seizure
The US Food and Drug Administration today (June 25) approved for the first time a marijuana-derived drug, Epidiolex, for the treatment of two rare forms
A high-fat and low-carbohydrate, or ketogenic, diet is used to treat children with refractory epilepsy. Olson et al. show that the ketogenic diet enriches populations
Centuries ago, humans believed that seizures were tied to the lunar cycle. Although scientific evidence for this association is scarce, physicians have long suspected that
In the suprachiasmatic nucleus, the brain’s central pacemaker, CLOCK (circadian locomotor output cycles kaput) is a transcription factor that plays a crucial role in regulating
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