Highlights •An unbiased genetic screen identifies effectors of AKT signaling as regulators of NMD •AKT phosphorylation of UPF1 overcomes autoinhibition of UPF1 helicase activity •AKT
Abstract The goal of this study was to determine whether a phosphodiesterase-4D (PDE4D) allosteric inhibitor (BPN14770) would improve cognitive function and behavioral outcomes in patients
When I visited Ricaurte, Colombia, in 2016, I was surrounded by men with long faces and prominent ears. As we spoke, they would ask repetitive
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