A team of researchers at the Gladstone Institutes in San Francisco, California, has used a version of CRISPR gene editing known as CRISPR interference (CRISPRi) to
For decades, researchers have known that forming memories requires that the expression and translation of some genes be upregulated in the brain. Unexpectedly, the mouse
The momentum of a cancer’s attack can be used against the cancer, say scientists who practice a form of molecular judo. Instead of directly blocking
By analyzing more than 1,600 samples representing 43 different tissues from 175 individuals, members of the international Genotype-Tissue Expression (GTEx) Consortium found that unique and
EDITOR’S CHOICE IN GENETICS & GENOMICS The paper J.D. Robin et al., “Telomere position effect: regulation of gene expression with progressive telomere shortening over long
Changes in gene methylation alone can trigger cancer, according to a mouse study published today (July 25) in the Journal of Clinical Investigation. Working in mouse
Mutations in one or more copies of mitochondrial DNA, known as heteroplasmies, are likely to be much more common in healthy people than previously anticipated.
Although small interfering RNAs (siRNAs) are largely explored today for their potential in gene therapy, the phenomenon was first described in plants, which employ siRNAs
Cell, Volume 147, Issue 7, 1484-1497, 23 December 2011. Abstract Tatjana Trcek, Daniel R. Larson, Alberto Moldón, Charles C. Query and Robert H. Singer. “Single-Molecule
Nature Methods 8, 853-859; doi:10.1038/nmeth.1703. Pimprapar Wongsrikeao, Dyana Saenz, Tommy Rinkoski,, Takeshige Otoi & Eric Poeschla. “Antiviral restriction factor transgenesis in the domestic cat“. Three
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