Noncoding RNA Drug Target for Colon Cancer Discovered
Long noncoding RNAs (lncRNAs) are, as the name suggests, long transcripts of RNA that do not code for proteins, but have been found to regulate
Long noncoding RNAs (lncRNAs) are, as the name suggests, long transcripts of RNA that do not code for proteins, but have been found to regulate
Summary Hundreds of genes influence how tall a person is, but most make an imperceptible difference—perhaps a millimeter, for example. Now, a group studying the
About one-quarter of genetic variants that are associated with autism spectrum disorder (ASD) are due to de novo mutations in protein-coding genes. Brandler et al.
CRISPR-Cas9 cleaves DNA, enabling genome editing. Surprisingly, three studies have concurrently uncovered an intrinsic RNA cutting activity of Cas9. Cas9 cuts endogenous RNA in some
Highlights •Wild-type KRAS expression affects cellular fitness in KRAS mutant LUAD •Wild-type KRAS expression impairs response to MEK inhibitors in KRAS mutant LUAD •Wild-type KRAS
Highlights •Somatic cell nuclear transfer (SCNT) using fetal fibroblasts yielded two live monkeys •Epigenetic modulators promoted development and pregnancy rate of SCNT embryos •SCNT using
The body’s own immune system could thwart some efforts to develop gene therapies based on the trendy genome-editing tool called CRISPR-Cas9, according to a study
Last Thursday (December 7), CRISPR Therapeutics submitted an application to European regulatory authorities seeking permission to begin clinical trials for CTX001, an investigational CRISPR treatment
Background: Shorter childhood telomere length (TL) and more rapid TL attrition are widely regarded as manifestations of stress. However, the potential effects of health interventions
EDITOR’S CHOICE IN NEUROSCIENCE The paper G.E. Doucet et al., “The role of intrinsic brain functional connectivity in vulnerability and resilience to bipolar disorder,” Am
Highlights •Trim-Away is a widely applicable method to degrade endogenous proteins •Target proteins do not need to be modified before degradation •Proteins are degraded within
Establishing the way in which a genetic alteration called a TMPRSS2-ERG gene fusion forms in a prostate cancer, rather than the presence of the gene
The blood–brain barrier (BBB) keeps neurotoxic plasma-derived components, cells, and pathogens out of the brain. An early BBB breakdown and/or dysfunction have been shown in
In the suprachiasmatic nucleus, the brain’s central pacemaker, CLOCK (circadian locomotor output cycles kaput) is a transcription factor that plays a crucial role in regulating
A signature event for organoids Human cancer genomes harbor cryptic mutational signatures that represent the cumulative effects of DNA damage and defects in DNA repair
CRISPR, the wildly popular genome-editing research tool, was invented in the West, but it is speeding toward potential human applications in China. Last week, the
A team of Chinese researchers who were the first to report having applied CRISPR to human embryos have done it again—this time upgrading their technique
Abstract Transient increases in mitochondrially-derived reactive oxygen species (ROS) activate an adaptive stress response to promote longevity. Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases produce ROS
Highlights •Metastases mostly disseminate late from primary breast tumors, keeping most drivers •Drivers at relapse sample from a wider range of cancer genes than in
With a few exceptions, cancers typically carry more than one driver mutation, sometimes five, ten, or more, and these driver mutations do not necessarily assort
For almost a century, Neandertals were considered the ancestors of modern humans. But now, in a new plot twist in the unfolding mystery of how
Densely packed tumour cells produce molecules that help them to migrate and spread, or metastasize, throughout the body. Daniele Gilkes at Johns Hopkins University in
From the dry valleys of Antarctica to the depths of a Welsh coal mine, a promised revolution in genome sequencing may finally be catching fire.
Mutations that activate Notch have been identified in several cancers. Weiland et al. find that Notch1 signaling within endothelial cells (ECs) promotes the invasion of
Some big ideas seem to appear out of nowhere, but in 2008 Chuan He deliberately went looking for one. The US National Institutes of Health
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