Highlights • Fasting mimicking diet induces prenatal-development gene expression in adult pancreas • FMD promotes Ngn3 expression to generate insulin-producing β cells • Cycles of
When is a mutation a true genetic variant? Large-scale sequencing studies have set out to determine the low-frequency pathogenic genetic variants in individuals and populations.
While 20–30% of colorectal cancers (CRCs) may arise from precursors with serrated glands, only 8–10% of CRCs manifest serrated morphology at diagnosis. Markers for distinguishing
Prions enter another domain of life Prions are self-propagating protein aggregates, discovered in connection with the fatal transmissible spongiform encephalopathies in mammals. Prions have also
Targeted genome editing via engineered nucleases is an exciting area of biomedical research and holds potential for clinical applications. Despite rapid advances in the field,
Determining the biological consequences of the thousands of genetic variants that contribute to common diseases is challenging. Genetic variants that influence autoimmune diseases have been
Determining the biological consequences of the thousands of genetic variants that contribute to common diseases is challenging. Genetic variants that influence autoimmune diseases have been
In gene editing, the kindest cut may be no cut at all. This possibility was explored by researchers working with peptide nucleic acids (PNAs), synthetic
The revolutionary gene editing technology CRISPR-Cas is on the verge of widespread application in agriculture, promising easy access to dramatic crop improvements. Companies now licensing
Spontaneously arising de novo mutations are likely important contributors to the development of autism spectrum disorder (ASD) in affected individuals. Genetic mutation is an ongoing
Recent advances in understanding different RNAs and unique features of their biology have revealed a wealth of information. However, approaches to identify small molecules that
Highlights •GOLM1 is identified as a leading gene relating to HCC metastasis •GOLM1 is correlated to early metastatic recurrence and poor survival of HCC patients
The term “life hacking” usually refers to clever tweaks that make your life more productive. But on p. 819, a team of scientists comes a
Increasing the levels of therapeutic proteins in vivo remains challenging. Antisense oligonucleotides (ASOs) are often used to downregulate gene expression1 or to modify RNA splicing2,
The vast majority of genes in sexually reproducing eukaryotes can recombine during the production of gametes. This reshuffling generates new genotypes that may provide selective
Chromatin structure stabilizes and compacts the genome to package it within the nucleus. This structure also serves as a dynamic regulator of gene expression, silencing
A study of a specific long noncoding RNA in a mouse model of breast cancer shows that knockdown of its expression suppresses metastasis.
The incidence of many types of cancer arising in organs with non-reproductive functions is significantly higher in male populations than in female populations, with associated
With recent approvals for multiple therapeutic antibodies that block cytotoxic T lymphocyte associated antigen 4 (CTLA4) and programmed cell death protein 1 (PD1) in melanoma,
A sweeping look at the DNA of more than half-a-million people has uncovered a surprise: A few individuals carry a genetic glitch that should make
Today being the 207th birthday celebration of renowned naturalist and evolutionary biologist Charles Darwin, it seemed only appropriate to discuss the recent findings of how
Preserving the distinction between research purposes and clinical applications, the Human Fertilisation and Embryology Authority (HFEA), a U.K. regulatory body, has approved the use of
A piece of noncoding DNA helps prevents cells from turning cancerous, and does so via two mechanisms. The noncoding DNA, which is called GNG12-ASI, acts
Are you the type of person that jumps out of bed bright-eyed and ready to take on the world? If so, your early morning cheeriness
Replacing the Y chromosome The mammalian Y chromosome encodes a specialized set of genes that are essential for male viability and fertility. In particular, the
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