Abstract Chimeric antigen receptor T cell (CAR-T) therapy is an emerging strategy to improve treatment outcomes for recurrent high-grade glioma, a cancer that responds poorly
Abstract The role of the nervous system in the regulation of cancer is increasingly appreciated. In gliomas, neuronal activity drives tumour progression through paracrine signalling
Abstract The epidermal growth factor receptor (EGFR) is frequently mutated in human cancer1,2, and is an important therapeutic target. EGFR inhibitors have been successful in
A new batch of prognostic cancer biomarkers have been discovered in an area where few have gone looking before. Researchers have unveiled a catalogue of
Highlights •In a retrospective study, ex vivo drug testing predicts GBM patient survival •Testing is based on detecting subtle changes in single-cell mass •Predictive power of functional testing
Glioblastoma is an aggressive type of cancer that can occur in the brain or spinal cord. It forms from cells called astrocytes that support nerve
Highlights •Macrophages induce the MES-like state of glioblastoma cells •Induction is mediated by macrophage-derived OSM interacting with OSMR/LIFR-GP130 •Subsets of glioblastoma-associated macrophages express a related
A golden opportunity to treat glioblastoma Glioblastoma (GBM) is a difficult cancer to treat, partly due to the blood-brain and blood-tumor barriers. Kumthekar et al. studied NU-0129,
With a survival rate of only five years, the most common and aggressive form of primary brain tumor, glioblastoma multiforme, is notoriously hard to treat
Abstract Glioblastomas harbor diverse cell populations, including rare glioblastoma stem cells (GSCs) that drive tumorigenesis. To characterize functional diversity within this population, we performed single-cell
More than 200 genes with novel and known roles in glioblastoma – the most aggressive type of brain cancer – offer promising new drug targets.
Scientists have identified an oncogene (a cancer-causing gene) responsible for glioblastoma, the deadliest brain tumor. The discovery offers a promising new treatment target for a
Highlights • PTEN deficiency in GBM drives macrophage infiltration via upregulation of LOX • LOX is directly regulated by YAP1 in PTEN-deficient GBM • LOX
Using longitudinal molecular profiling, Körber et al. propose in this issue of Cancer Cell that IDH-wild-type glioblastomas initiate years pre-diagnosis with chromosome-level alterations that drive
Highlights • Glioma stem cells home toward, invade, and proliferate in human cerebral organoids • GLICO (cerebral organoid glioma) tumors phenocopy patient glioblastoma • Tumor
Hotspot mutations in isocitrate dehydrogenase 1 ( IDH1) and isocitrate dehydrogenase 2 ( IDH2) occur in a variety of myeloid malignancies and solid tumors. Mutant
Agenetically modified poliovirus given to patients with recurrent glioblastoma—an advanced form of brain cancer—appears to lengthen survival times, researchers reported today (June 26) in the
Agenetically modified poliovirus given to patients with recurrent glioblastoma—an advanced form of brain cancer—appears to lengthen survival times, researchers reported today (June 26) in the
Agenetically modified poliovirus given to patients with recurrent glioblastoma—an advanced form of brain cancer—appears to lengthen survival times, researchers reported today (June 26) in the
Glioblastoma, a highly malignant and usually fatal form of brain cancer, is resistant to treatment in part because it can quickly develop resistance to both
Highlights •NOTCH signaling is preferentially activated in glioblastoma stem cells •GSIs have limited activities against glioblastoma stem cells •FTIs improve response to GSIs in vitro
In this issue of Cancer Cell, Saha et al. systematically test and optimize combination therapy strategies in a challenging model of glioblastoma. Durable complete responses
Neural stem cells (NSCs) are ideal recruits for search-and-destroy missions in the brain. They have an innate ability to home in on cancer cells, and
Glioblastoma multiforme (GBM) is a deadly brain cancer, and a major challenge to its treatment with radiation is that the approach often leads to an
Scientists at Dartmouth’s Norris Cotton Cancer Center (NCCC) say they have identified the functional role of two distinct DNA modifications in glioblastoma (GBM) tissues. The
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