Abstract Whether CD8+ T lymphocytes control human immunodeficiency virus infection by cytopathic or non-cytopathic mechanisms is not fully understood. Multiple studies highlighted non-cytopathic effects, but one
Highlights Summary HIV-1 encounters the hierarchically organized host chromatin to stably integrate and persist in anatomically distinct latent reservoirs. The contribution of genome organization in
Abstract Despite scientific evidence originating from two patients published to date that CCR5Δ32/Δ32 hematopoietic stem cell transplantation (HSCT) can cure human immunodeficiency virus type 1
Abstract After viral entry and reverse transcription, HIV-1 proviruses that fail to integrate are epigenetically silenced, but the underlying mechanism has remained unclear. Using a
Analyzing antibodies A challenge for HIV-1 vaccine development is the need to induce a polyclonal neutralizing antibody (nAb) response in vaccine recipients. Here, Saunders et al. vaccinated
A new mouse study by researchers from Tel Aviv University and collaborators demonstrates a potential new treatment for AIDS which may be developed into a
Evolving virulence in HIV Changes in viral load and CD4+ T cell decline are expected signals of HIV evolution. By examining data from well-characterized European cohorts,
Abstract Broadly neutralizing antibodies (bNAbs) targeting the HIV-1 envelope glycoprotein (Env) are promising molecules for therapeutic or prophylactic interventions. Beyond neutralization, bNAbs exert Fc-dependent functions
Abstract HIV is difficult to eradicate due to the persistence of a long-lived reservoir of latently infected cells. Previous studies have shown that natural killer
A recent study published in the journal Nature Medicine, led by researchers James Riley, PhD, a professor of Microbiology at the Perelman School of Medicine at
Ever since the first cases of a mysterious disease in the early 1980s exploded into the HIV/AIDS pandemic, researchers have been searching for ways to
Scientists at Sanford Burnham Prebys Medical Discovery Institute have created a next-generation drug called Ciapavir (SBI-0953294) that is effective at reactivating dormant human immunodeficiency virus (HIV). The
A study published in Nature Medicine that found an increased mortality rate in people with an HIV-preventing gene variant has a major flaw, according to
Scientists extracted a near-complete HIV-1 genome from a lymph node that had been preserved in wax for more than 50 years. The sample stands as
A few years ago, microbiologist Catherine Lozupone and colleagues at the University of Colorado were studying metabolism-related health problems in men and women infected with
A study published today (June 3) in Nature Medicine confirms previous reports that a variant of the gene CCR5 that protects against infection by HIV
Broadly neutralizing monoclonal antibodies protect against infection with HIV-1 in animal models, suggesting that a vaccine that elicits these antibodies would be protective in humans.
In a study published yesterday (May 2) in The Lancet, researchers report that out of 782 gay male couples where one individual was HIV positive
A person with HIV seems to be free of the virus after receiving a stem-cell transplant that replaced their white blood cells with HIV-resistant versions.
Long-acting medicines have proved as effective as daily pills in preventing HIV from replicating, according to results from twin trials that enrolled more than 1,000
For the second time, a person living with HIV appears to have cleared the virus after a stem cell transplant replaced his infected immune cells
Antiviral drugs prevent HIV from replicating, but the virus can hide in the cells of infected individuals in a non-replicating, latent form. A two-pronged approach
A mix of two monoclonal antibodies against HIV tamped down virus levels in patients not taking antiretroviral medication, according to the results of two early-stage
More than 500 organizations from 67 countries have now endorsed a campaign promoting awareness that virally suppressed HIV-positive people cannot sexually transmit HIV. Launched in
Researchers have a new way to understand the much-studied Berlin patient’s unexpected cure from HIV and improve outcomes of stem cell transplants for patients with
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