Researchers have a new way to understand the much-studied Berlin patient’s unexpected cure from HIV and improve outcomes of stem cell transplants for patients with
When a virus invades a host cell, it needs to do some remodeling to make the environment safe for itself. In recent years, researchers have
A minor proportion of people harbor a homozygous mutation in CCR5—a gene that encodes a receptor found on immune cells—that thwarts HIV’s attempts to get
In 2015, 17 million HIV-infected individuals worldwide were on antiretroviral drug therapies, which are remarkably effective in suppressing the virus. Yet, 6000 people a day
The first reports of the disease that would later be known as HIV/AIDS came in 1981, when AIDS-related conditions were already on the rise, particularly
An antibody to block viral fusion A small fraction of HIV-1–infected individuals develop broad and potent antibodies that bind the HIV-1 envelope protein (Env). These
CRISPR/Cas9 gene editing has shown remarkable therapeutic potential, including the ability to fightpathogens like HIV. But the same process that inactivates the deadly virus may
For HIV to develop into full-blown AIDS, the virus must deplete a subset of immune cells called CD4+ T cells, disabling an infected person’s adaptive
Scientists at UC Davis have found that early exposure to inflammatory cytokines, such as interleukin 2, can stymie the activity of CD4 T cells, immune
An oft-overlooked group of immune cells, natural killer (NK) cells seem to have a paradoxical role when it comes to viral infections in particular, HIV.
The only HIV vaccine to show promising efficacy in clinical trials stimulated an antibody-based defense in some individuals but not in others. Analyzing patients’ samples
Broadly neutralizing antibodies, those that could squash a wide swath of virus types, are the supreme goal of HIV vaccine development. Although some people infected
A two-armed molecule has been developed that effectively locks HIV in a kind of miniature full nelson, preventing the virus from wrestling its way into
Scientists at the Harvard Stem Cell Institute at Massachusetts General and Boston Children’s hospitals say that a novel gene editing method has been used to
HIV’s envelope protein (Env) coats virus particles and allows HIV to enter host cells. HIV entry is highly dynamic. Env proteins work in groups of
HIV’s envelope protein (Env) coats virus particles and allows HIV to enter host cells. HIV entry is highly dynamic. Env proteins work in groups of
Like other retroviruses, the genetic material of HIV wedges itself into the genome of its human host. While antiretroviral therapies are effective at repressing HIV,
Scientists have uncovered two new cases of HIV patients in whom the virus has become undetectable. The two patients, both Australian men, became apparently HIV-free
Timothy Ray Brown, the “Berlin patient,” was the first person reported to be cured of HIV. He has shown no signs of infection for five
A treatment that previously eliminated HIV infection from a Mississippi infant will be tested in a clinical trial, Nature reported. Newborns with possible HIV infections will be given a
For the first time, a plant-produced antibody gets the green light for clinical trials in the United Kingdom. A monoclonal antibody produced in the leaves
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