Microbiota-dependent activation of the myeloid calcineurin-NFAT pathway inhibits B7H3- and B7H4-dependent anti-tumor immunity in colorectal cancer
Highlights •Microbial recognition activates myeloid calcineurin and NFAT in colorectal cancer •NFAT-dependent IL-6 promotes expression of co-inhibitory B7H3 and B7H4 by tumors •B7H3/B7H4 inhibit CD8+ T cells