A London baby with end-stage leukemia has received a remarkable new cancer treatment: off-the shelf T cells with several gene modifications. Doctors say it’s too
By introducing a particular strain of bacteria into the digestive tracts of mice with melanoma, researchers at the University of Chicago were able to boost
Although best known for their pathogen-fighting prowess, T lymphocytes also ensure that the immune response does not run amok. A subset of T cells called
The only HIV vaccine to show promising efficacy in clinical trials stimulated an antibody-based defense in some individuals but not in others. Analyzing patients’ samples
Lung cancer is the most common malignancy worldwide and is a focus for developing targeted therapies due to its refractory nature to current treatment. We
last December, scientists at Juno Therapeutics reported at the American Society of Hematology (ASH) meeting that, in an ongoing Phase 1 trial, its chimeric antigen
Widespread uncontrolled inflammation, multiple organ failure, and death were the results of lymphocytic cytomegalovirus (LCMV) infection in mice that had been immunized with a vaccine
When immunologist Michel Sadelain launched his first trial of genetically engineered, cancer-fighting T cells in 2007, he struggled to find patients willing to participate. Studies in
Patients with advanced melanoma can survive longer after treatment with the immunotherapy drug ipilimumab. Kvistborg et al. show how this therapeutic antibody exerts its beneficial effects. Although
The hypoxic conditions within tumours are implicated in resistance to therapy, but might provide the ideal environment for the growth of anaerobic bacteria capable of
Therapeutic transfer of virus-specific T cells to immunocompromised patients can help battle life-threatening infections, but the process for generating such cells is lengthy and laborious.
Limited evidence exists that humans mount a mutation-specific T cell response to epithelial cancers. We used a whole-exomic-sequencing-based approach to demonstrate that tumor-infiltrating lymphocytes (TIL)
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