Abstract The obesity epidemic continues to worsen worldwide, driving metabolic and chronic inflammatory diseases. Thiazolidinediones, such as rosiglitazone (Rosi), are PPARγ agonists that promote ‘M2-like’
Abstract Insulin resistance is the primary pathophysiology underlying metabolic syndrome and type 2 diabetes1,2. Previous metagenomic studies have described the characteristics of gut microbiota and
Researchers have discovered a previously unknown way that pancreatic cells decide how much insulin to secrete. It could provide a promising new target to develop
An international team of researchers has successfully reprogrammed human α cells into insulin-producing β cells, according to a study published yesterday (February 13) in Nature.
A recent decrease in the incidence of type 1 diabetes in Australian children may be linked to the introduction of a routine vaccine against rotavirus,
During development, cells proliferate and differentiate to enable organs to achieve their final functional architecture1. As cells develop to reach their mature state, they respond
Researchers have successfully treated animals with a mouse version of type 1 diabetes by inducing pancreatic cells that don’t normally produce insulin to manufacture the
In this issue of JEM, Marciniak et al. (https://doi.org/10.1084/jem.20161731) identify a putative novel function of tau protein as a regulator of insulin signaling in the
Engineering cells to regulate glucose Diabetes mellitus affects hundreds of millions of people worldwide. Blood glucose levels are chronically deregulated in diabetics, and this can
Between October 2013 and July 2014, six healthy, middle-aged men reported to Temple University Hospital in north Philadelphia. For seven days, researchers confined each subject
Cold exposure may be a potential therapy for diabetes by increasing brown adipose tissue (BAT) mass and activity. Here we report that 10 d of
The device: A patch containing 121 microneedles loaded with specialized nanoparticles designed to release insulin when glucose levels are high could make insulin delivery a
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