Abstract Microglia are emerging as key drivers of neurological diseases. However, we lack a systematic understanding of the underlying mechanisms. Here, we present a screening
Highlights •FOXG1 syndrome neural progenitor cells show slower G1 phase exit and proliferation •FOXG1 syndrome neural progenitor cells have increased frequency of primary cilia •Engineered FOXG1 dose correlates with
Highlights •ApoE4 ACM induces neuronal lipid raft expansion and Aβ42 overproduction •Co-localization of lipid rafts and APP increases in neurons by ApoE4 ACM •Increasing cholesterol in
Cell therapies to treat cardiac damage have been moving through clinical trials, with mixed results. Often, stem cells are taken from a patient’s bone marrow
A woman in Japan with a corneal disease has become the first person in the world to receive a corneal transplant made from induced pluripotent
The Japanese government’s health ministry has given the go-ahead for a trial of human induced pluripotent stem cells to treat spinal cord injury, Reuters reports
In 2018, scientists rode the activist momentum of 2017 to step out of the lab and into the public sphere: There was an unprecedented surge
In October, researchers at Kyoto University transplanted cells generated from induced pluripotent stem cells into the brain of a man with Parkinson’s disease, the scientists
With their pluripotency and ability to self-renew, some cancer cells have been likened to stem cells. Now, researchers show that the similarities between the cells
The promise of cell-based therapy is limited by the challenge of generating large enough numbers of the correct type of cells. But a strategy called
Scientists have for this first time reprogrammed murine embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) into fully functional oocytes in the laboratory.
Cardiac muscle cells derived from induced pluripotent stem cells (iPSCs) and injected into monkeys helped the animals’ hearts recover from a heart attack, according to
Donor stem cell–derived retinal epithelial cells whose immune proteins correspond to those of a recipient are tolerated following transplant into monkeys’ eyes, according to a
Pain can be tough to take, and it’s also difficult to study: rodent models for pain do not necessarily translate to human pain conditions and
Retinitis pigmentosa, an inherited disease causing progressive degeneration of the retina, is repsonsible for blindness in approximately 1.5 million people worldwide. Using patient-derived stem cells,
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