In some patients with cancer, tumors don’t shrink in response to chemotherapy and these patients are more likely to develop metastatic cancer. Mouse studies have
A combination of chemotherapy and immunotherapy slows disease progression in patients with metastatic triple-negative breast cancer, according to results published Saturday (October 20) in the
Highlights The metastatic cascade is associated with metabolic rewiring. Metabolic rewiring supports cancer invasion by inducing signaling pathways. Circulating tumor cells rely on enhanced antioxidant
In cancer, the epithelial-to-mesenchymal transition (EMT) is associated with tumour stemness, metastasis and resistance to therapy. It has recently been proposed that, rather than being
Not only the number of migrating cancer cells determines the risk for metastasis but also their characteristics, scientists from the German Cancer Research Center (DKFZ)
Cancer organoids to model therapy response Cancer organoids are miniature, three-dimensional cell culture models that can be made from primary patient tumors and studied in
Using a process called in situ vaccination, in which the host’s immune system is recruited to attack cancer cells, researchers were able to clear injected
Nanoparticles designed to selectively deliver the drug niclosamide to cancer stem cells caused the cancer stem cells to lose their stem-like properties and rendered them
In this issue of JEM, Sundaram et al. (https://doi.org/10.1084/jem.20170354) report a mechanism by which the normal epithelial wound healing response is “hijacked” to promote invasion
Highlights •Metastases mostly disseminate late from primary breast tumors, keeping most drivers •Drivers at relapse sample from a wider range of cancer genes than in
Reciprocal interactions between tumor cells and their microenvironment drive cancer progression and therapy resistance. In this issue, Nabet et al. demonstrate that dynamic feedback between
Metastasizing cancer cells travel through the lymphatic vasculature, but it’s not clear what role the formation of lymph vessels, called lymphangiogenesis, plays in cancer progression.
“What did the lymph nodes show?” is the question whose answer is apprehensively awaited by every colon cancer patient. Even in the age of molecular
Densely packed tumour cells produce molecules that help them to migrate and spread, or metastasize, throughout the body. Daniele Gilkes at Johns Hopkins University in
Neutrophil extracellular traps (NETs), made of processed chromatin bound to cytotoxic enzymes, are released by neutrophils into the extracellular space to control microbial infections. However,
Tumor cells undergoing metastasis prompt neutrophils to extrude stringy DNA webs known as neutrophil extracellular traps (NETs) that help the cancer invade other tissues, according
Highlights •GOLM1 is identified as a leading gene relating to HCC metastasis •GOLM1 is correlated to early metastatic recurrence and poor survival of HCC patients
Dying tumor cells release the phospholipid S1P, which stimulates proinflammatory responses in tumor-associated macrophages, including secretion of the protein lipocalin-2. Jung et al.discovered that in
Clusters of circulating tumor cells (CTCs) may play a larger role in cancer metastasis than previously thought. Researchers at Massachusetts General Hospital have now shown
Tumor Heterogeneity and Plasticity Both genetic and phenotypic tumor heterogeneity (see Glossary) are important contributing factors to therapy resistance and tumor regrowth. During tumor progression,
Emerging evidence suggests that metastasis the spread of cancer from one organ or tissue to another—is aided by a significant remodeling of the cancer cells’
In order to develop a better understanding of the mechanisms that cause some cancer cells to break away from the primary tumor and migrate to
The technique: Researchers at MIT and the University of California, San Diego, have programmed a probiotic Escherichia coli strain to detect cancer metastases in the
Tumor cells appear more likely to metastasize if they are studded with too much Frizzled2, a kind of cell receptor, along with Wnt5, a signaling
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