Highlights Summary Immunosuppressive tumor microenvironments (TMEs) reduce the effectiveness of immune responses in cancer. Mesenchymal stromal cells (MSCs), precursors to cancer-associated fibroblasts (CAFs), promote tumor
Abstract Squamous cell carcinomas are triggered by marked elevation of RAS–MAPK signalling and progression from benign papilloma to invasive malignancy1,2,3,4. At tumour–stromal interfaces, a subset
A Ludwig Cancer Research study has profiled, in a large comparative analysis, the distinct immune landscapes of tumors that arise in the brain (gliomas) and
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