Highlights Summary Glucocorticoids are important for proper organ maturation, and their levels are tightly regulated during development. Here, we use human cerebral organoids and mice
Abstract The expansion of the neocortex, a hallmark of mammalian evolution1,2, was accompanied by an increase in cerebellar neuron numbers3. However, little is known about
Highlights •hPSC maintenance conditions influence the quality of cortical organoid formation •Identification of an intermediate pluripotency state optimal for cortical organoids •MEF feeder support enhances
In a study led by National Institutes of Health (NIH) researchers, scientists found that five genes may play a critical role in determining whether a
Researchers have generally believed that the survival of neurons is determined nearly extrinsically, such as the tissues and cells that neurons supply with nerve cells.
Summary The occurrence of dreaming during rapid eye movement (REM) sleep prompts interest in the role of REM sleep in hippocampal-dependent episodic memory. Within the
Neuroscientist Gregor Pilz of the University of Zurich has watched stem cells turn into neurons in the brains of young, living mice—a feat that not
The human brain has undergone substantial change since humans diverged from chimpanzees and the other great apes1,2. However, the genetic and developmental programs that underlie
For a small fold of tissue, the hippocampus has an outsized influence. It stores and retrieves human memories, capturing the life history that makes us
It’s well established that exercise is good for the mammalian brain. As early as 1999, researchers discovered considerably more newborn neurons in the hippocampi of
Mice that model a severe form of Alzheimer’s disease tend to exhibit improved memory after exercise-induced neuron production, according to a report in Science today
If youngsters told their elders to be quiet, stress levels would surely rise. But, when it comes to brain cells, it seems the opposite is
Adult human hippocampi are home to thousands of immature neurons, researchers report today (April 5) in Cell Stem Cell. The result runs counter to a
New neurons may not develop in the adult human brain as neuroscientists for years have come to believe. Researchers studying postmortem brain tissue of humans
People who experience blast-related trauma to the brain, a condition that has become more and more common among combat veterans, can later experience depression and
Neural stem cells normally go with the flow of chemical guides. But with a little electrical stimulation they can be coaxed to go the other
Newly made cells in the brains of mice adopt a more complex morphology and connectivity when the animals encounter an unusual environment than if their
Zika virus exposure in a mouse model can infect adult neural stem cells in the brain, leading to cell death and reduced proliferation.CELL STEM CELL,
Working out is good for the brain. Now, a team of scientists from the U.S. and Germany has a clearer idea why. A protein called
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