Abstract Kaposi’s sarcoma-associated herpesvirus (KSHV) is an oncogenic double-stranded DNA virus and the etiologic agent of Kaposi’s sarcoma and hyperinflammatory lymphoproliferative disorders. Understanding the mechanism
Abstract Most cancers exhibit aneuploidy, but its functional significance in tumor development is controversial. Here, we describe ReDACT (Restoring Disomy in Aneuploid cells using CRISPR Targeting), a set of
RNA surveillance turns oncogenic Precise RNA regulation is a quality control mechanism that is important for normal development and to prevent disease. Aberrant RNAs require
Abstract BACKGROUND Although hypomethylating agents are currently used to treat patients with cancer, whether they can also reactivate and up-regulate oncogenes is not well elucidated.
Scientists have identified an oncogene (a cancer-causing gene) responsible for glioblastoma, the deadliest brain tumor. The discovery offers a promising new treatment target for a
Cancer cells signal to nontransformed cells and to other transformed cells to generate an environment that is amenable for their growth. Zhang et al. noticed
Highlights •Inflammation is associated with changes in the chromatin landscape of MPN cells •NF-κB is constitutively active in MPNs and drives MPN-associated inflammation •JQ1 shows
The mutant form of the GTPase KRAS is a key driver of pancreatic cancer but remains a challenging therapeutic target. Exosomes are extracellular vesicles generated
It is not easy being a cancer cell, so such cells may need help from factors other than oncogenes that contribute to the cancer cell
Myc, a transcriptional regulator that is overexpressed in several human cancers, appears to have a direct role in preventing immune cells from efficiently attacking tumor
Analysis of the 3D structure of DNA in tumour cells reveals how mutations in the IDH1 gene, and associated changes in methyl groups attached to
KRAS is one of the most frequently mutated oncogenes in human cancer. Despite substantial efforts, no clinically applicable strategy has yet been developed to effectively
Created by ePubSystems. Contact Us for similar site for your university or institute.