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Fighting Malaria Drug Resistance

Plasmodium falciparum resistance to artemisinin-based combination therapies (ACTs) started to crop up around 2007. Infections, especially in the Greater Mekong area of Southeast Asia, seemingly survived treatment. This was largely due to the pairing...

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A new road to cancer-drug resistance

The development of resistance to cancer therapy is a major predictor of patient mortality. Therefore, understanding resistance mechanisms is key to improving therapeutic outcomes. Writing in Nature, He et al.1 report their discovery of...

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Rethinking aspirin use

Low-dose aspirin is a popular daily prevention strategy for individuals with a history of heart attack or stroke, owing to aspirin’s ability to reduce the clotting action of blood, which is often compromised in...

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Nanoscreening for drug combinations

Biological networks are complex, and effective therapies may require combinations of drugs to overcome redundancies, feedback mechanisms, or drug resistance. Such screening is challenging because of the multiplicity of combinations to test. Kulesa et...

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Coatings join the fight against bacteria

Efforts to combat the spread of infections, especially in health care settings, mostly involve the use of antibacterial cleaning agents and antibiotic drugs. Another possible strategy is the use of coatings that are antibacterial...

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Hidden conflicts?

An investigative report uncovers little recognized and unpoliced potential conflicts of interest among those who serve on FDA advisory panels that review drugs. Some members of such panels are later receiving significant payments from...

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Two Vaccines Are Better Than One for Malaria

The tenacity of the malaria parasite has all too often made it intractable to long-term therapeutic intervention. The development of parasite drug resistance is almost an inevitability, causing public health organizations to rethink treatment...

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How Bacteria Eat Penicillin

Some bacteria take antibiotic resistance a step further: they chow down on the very compounds designed to kill microbes and use them as fuel. Researchers detail today (April 30) in Nature Chemical Biology how...

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