As the opioid crisis continues to ravage U.S. communities, scientists and drug companies have intensified their efforts to develop safer and less addictive pain medications.
Biological networks are complex, and effective therapies may require combinations of drugs to overcome redundancies, feedback mechanisms, or drug resistance. Such screening is challenging because
Efforts to combat the spread of infections, especially in health care settings, mostly involve the use of antibacterial cleaning agents and antibiotic drugs. Another possible
An investigative report uncovers little recognized and unpoliced potential conflicts of interest among those who serve on FDA advisory panels that review drugs. Some members
The US Food and Drug Administration today (June 25) approved for the first time a marijuana-derived drug, Epidiolex, for the treatment of two rare forms
The tenacity of the malaria parasite has all too often made it intractable to long-term therapeutic intervention. The development of parasite drug resistance is almost
Addressing a critical issue for people with a genetic disorder called tuberous sclerosis complex (TSC), doctors at The University of Texas Health Science Center at
Amgen and Novartis are set to commercially launch the first calcitonin gene-related peptide (CGRP) receptor inhibitor in the U.S. next week following FDA approval yesterday
Due to advances in rare-disease research and individualized cell and gene therapies, there has been a recent crop of treatments approved by regulatory agencies not
Some bacteria take antibiotic resistance a step further: they chow down on the very compounds designed to kill microbes and use them as fuel. Researchers
At the annual American Society of Clinical Oncology meeting last June, Bristol-Myers Squibb (BMS) researchers presented data on a cohort of patients not responding to
The National Institutes of Health (NIH) will exclusively use taxpayer money for a research initiative on the treatment of pain and substance use disorder, STAT
For as long as there has been civilization, there have been mind-altering drugs. Alcohol has been around for at least 10,000 years, but recent advances
Powerful chemical countermeasures could one day enter the battle against opioid addiction, which killed more than 42,000 people in the United States in 2016. Doctors
Bacterial pathogens show a remarkable capacity to stick to host tissues and implanted biomaterials, grow, and form biofilms on these surfaces (1). These multicellular communities
What is a best-selling drug worth? In 2013, at least, it came down to at least $3 billion in annual sales—triple the $1 billion benchmark
In 2014, Miriam van Staveren went on holiday to the Canary Islands and caught an infection. Her ear and sinuses throbbed, so she went to
Extensive surgery involving mastectomy and removal of several lymph nodes can be safely avoided for more women with some types of breast cancer, if they
In the 1990s, pharmacologist Dave Sharp of the University of Texas’s Barshop Institute for Longevity and Aging Studies in San Antonio was studying mice with
Researchers at Emory Health Sciences have detected “heteroresistance” to colistin, a last-resort antibiotic, in already highly resistant Klebsiella pneumoniae. Their study (“Carbapenem-Resistant Klebsiella pneumoniae Exhibiting
Cancer organoids to model therapy response Cancer organoids are miniature, three-dimensional cell culture models that can be made from primary patient tumors and studied in
Abstract BACE1 initiates the generation of the β-amyloid peptide, which likely causes Alzheimer’s disease (AD) when accumulated abnormally. BACE1 inhibitory drugs are currently being developed
Scientists from King’s College London have found a way to boost the immune system to help it fight back against cancer. The breakthrough involves the
Studying scorpions comes with its share of danger, as biologist Bryan Fry of the University of Queensland knows all too well. On a 2009 trip
Highlights •GPCRs targeted by FDA-approved drugs show genetic variation in the human population •Genetic variation occurs in functional sites and may result in altered drug
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