Countering TB prodrug resistance The arsenal of antibiotics for treating tuberculosis (TB) contains many prodrugs, such as ethionamide, which need activation by normal metabolism to
Update (March 13): In an open letter published last week (March 6), members of the Stop TB Partnership wrote that the WHO’s decision to leave
Modern technology and modern medical practice have evolved over the past decades, enabling us to enhance and extend human life to an unprecedented degree. The
The morbidity and economic tolls of influenza virus are huge, regardless of its capacity to kill. Vaccines and therapies to control this persistent threat are
Over the past few decades, the number of deaths from cardiovascular disease has declined substantially in developed countries. Statins, drugs that lower serum levels of
Summary More than 10 years after peak of the “mad cow disease” epidemic that killed more than 200 people in Europe, the threat of the
Overweight parents could be at risk of having children with impaired development, according to a study published January 3 in Pediatrics. Researchers found that children
BACKGROUND The escalating crisis of multidrug resistance is raising fears of untreatable infections caused by bacterial “superbugs.” However, many patients already suffer from infections that
On 26 January, Ling Wang and Qinzi Xu, two biomedical scientists at the University of Pittsburgh in Pennsylvania, placed a mouse under a chemical hood,
Summary Points A recent high profile report estimates that, by 2050, 10 million people will die every year due to antimicrobial resistance (AMR) unless a
The spread of antibiotic resistance is a major public health concern. Czekalski et al. investigate whether ozonation of wastewater can help to combat this spread
Lose weight, gain it back. That’s the frustrating routine for many individuals who have experienced only short-term success with diets. To examine the microbial and
Although Zika virus (ZIKV) has been detected in the semen of men months after initial infection, the consequences of retention of the virus in the
Between 5% and 10% of cystic fibrosis (CF) patients become infected with Mycobacterium abscessus, a pathogen that thrives in the excess of thick mucus amassing
A colonoscopy can find and remove cancerous growths in the colon, but it may not provide much cancer prevention benefit after the age of 75,
Attendees at the 2015 Genitourinary Cancers Symposium in Orlando, Florida, were presented with a head scratcher. At a poster session on renal cancer, a team
Highlights •Caloric restriction leads to preferential glucose uptake in white fat •Caloric restriction promotes the development of functional beige fat •Decreased caloric intake enhances type
Zika virus exposure in a mouse model can infect adult neural stem cells in the brain, leading to cell death and reduced proliferation.CELL STEM CELL,
The hepatitis E virus is best known as a waterborne pathogen that occasionally causes big outbreaks in Asia and Africa. But more recently, scientists have
The hepatitis E virus is best known as a waterborne pathogen that occasionally causes big outbreaks in Asia and Africa. But more recently, scientists have
In 1927, Austrian physician Julius Wagner-Jauregg won the Nobel Prize in Physiology or Medicine for his discovery of the therapeutic value of malaria inoculation in
Obesity is more prevalent in patients with a history of cancer than in the general population and survivors of colorectal and breast cancers are particularly
ommon mechanisms in aging and obesity are hypothesized to increase susceptibility to neurodegeneration, however direct evidence in support of this hypothesis is lacking. We therefore
In June, Dutch scientists finished the largest study yet to find out whether erythropoietin (EPO), a drug popular among professional cyclists, really enhances athletic performance.
In June, Dutch scientists finished the largest study yet to find out whether erythropoietin (EPO), a drug popular among professional cyclists, really enhances athletic performance.
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