Abstract Timely repair of chromosomal double-strand breaks is required for genome integrity and cellular viability. The polymerase theta-mediated end joining pathway has an important role
Abstract The transferability and clinical value of genetic risk scores (GRSs) across populations remain limited due to an imbalance in genetic studies across ancestrally diverse
Highlights Summary During the progression of type 1 diabetes (T1D), β cells are exposed to significant stress and, therefore, require adaptive responses to survive. The
Abstract How cell metabolism regulates DNA repair is incompletely understood. Here, we define a GTP-mediated signaling cascade that links metabolism to DNA repair and has
Abstract Raynaud’s phenomenon (RP) is a common vasospastic disorder that causes severe pain and ulcers, but despite its high reported heritability, no causal genes have
Abstract The application of RNA interference (RNAi) to mammalian cells has provided the means to perform phenotypic screens to determine the functions of genes. Although
Editor’s summary The current opioid crisis emphasizes the need for nonaddictive pain treatments. Here Perez-Sanchez and colleagues evaluated whether direct inhibition of pain-related hyperactivity in
Abstract DNA base editors use deaminases fused to a programmable DNA-binding protein for targeted nucleotide conversion. However, the most widely used TadA deaminases lack post-translational
Abstract The ever-growing compendium of genetic variants associated with human pathologies demands new methods to study genotype–phenotype relationships in complex tissues in a high-throughput manner1,2.
Abstract MicroRNAs (miRNAs) exert their gene regulatory effects on numerous biological processes based on their selection of target transcripts. Current experimental methods available to identify
Highlights Summary The somatic mutations found in a cancer genome are imprinted by different mutational processes. Each process exhibits a characteristic mutational signature, which can
Significance DNA and RNA deformations play crucial roles in biological processes, such as DNA packaging and nucleic acid recognition by proteins. The relevant understanding is
Abstract Multispecific antibodies have emerged as versatile therapeutic agents, and therefore, approaches to optimize and streamline their design and assembly are needed. Here we report
Significance Neurological diseases are often thought to be irreversible, including hearing loss. In this study, we found that one type of hearing loss can be
Editor’s summary Skin pigmentation provides crucial protection from the DNA damage caused by sun exposure, but the production of melanin in the skin and hair
Abstract The trait of participating in a genetic study probably has a genetic component. Identifying this component is difficult as we cannot compare genetic information
Abstract Telomere length in humans is associated with lifespan and severe diseases, yet the genetic determinants of telomere length remain incompletely defined. Here we performed
Abstract Cell-free genetically encoded biosensors have been developed to detect small molecules and nucleic acids, but they have yet to be reliably engineered to detect
Highlights Summary The “inactive” X chromosome (Xi) has been assumed to have little impact, in trans, on the “active” X (Xa). To test this, we quantified Xi and
Abstract Polygenic scores (PGSs) have limited portability across different groupings of individuals (for example, by genetic ancestries and/or social determinants of health), preventing their equitable
Abstract Mirror movements (MM) disorder is characterized by involuntary movements on one side of the body that mirror intentional movements on the opposite side. We
Abstract Background We aimed to establish the causal effects of lowering sclerostin, target of the anti-osteoporosis drug romosozumab, on atherosclerosis and its risk factors. Methods
Structured Abstract INTRODUCTION Deciphering the molecular and genetic changes that differentiate humans from our closest primate relatives is critical for understanding our origins. Although earlier
Abstract The approximately 120 MDa mammalian nuclear pore complex (NPC) acts as a gatekeeper for the transport between the nucleus and cytosol1. The central channel of the
Abstract In the early stages of mitosis, cohesin is released from chromosome arms but not from centromeres. The protection of centromeric cohesin by SGO1 maintains
Created by ePubSystems. Contact Us for similar site for your university or institute.