An osteocalcin-deficient mouse strain without endocrine abnormalities
Abstract Osteocalcin (OCN), the most abundant noncollagenous protein in the bone matrix, is reported to be a bone-derived endocrine hormone with wide-ranging effects on many
Abstract Osteocalcin (OCN), the most abundant noncollagenous protein in the bone matrix, is reported to be a bone-derived endocrine hormone with wide-ranging effects on many
Abstract For some diseases, successful vaccines have been developed using a nonpathogenic counterpart of the causative microorganism of choice. The nonpathogenicity of the rodent Plasmodium berghei (Pb)
Adult heart muscle cells (cardiomyocytes) cannot regenerate after ischemic injury. However, neonatal cardiomyocytes do regenerate. Cui et al. undertook single-nucleus RNA sequencing of cardiomyocytes to find out
Repaired β cells for replacement therapy Wolfram syndrome is a recessive genetic disease caused by mutations in WFS1 (Wolfram syndrome 1) and can present with a multitude
Understanding how normal tissues give rise to cancer is crucial for improving prevention and early detection of this deadly disease. Over the past two decades,
The first single-cell analysis of the human ovarian cortex revealed six main types of cells, but none of the oogonial stem cells that other researchers
A person with a genetic condition that causes blindness has become the first to receive a CRISPR–Cas9 gene therapy administered directly into their body. The
CRISPR takes first steps in humans CRISPR-Cas9 is a revolutionary gene-editing technology that offers the potential to treat diseases such as cancer, but the effects
Highlights • 664 patients and 154 CFTR mutations represented in an organoid biobank • Adenine base editors enable efficient repair of nonsense mutations in CFTR
Highlights The literature describing the differences in microbiota features between individuals with cancer and matched controls has undergone dramatic recent expansion. Mechanistic models for how
Although neurobiologist Oded Rechavi comes from a family of doctors and researchers, it was not his original plan to go into science. “It wasn’t something
Researchers have shown previously that excessive proliferation of the cells of the brain, which can cause macrocephaly, or large head size, is associated with autism.
Female of most mammalian species are fertile throughout their adult life. But humans are different, says University of Copenhagen molecular geneticist Eva Hoffmann. A woman’s
It started out as “sort of a stupid thing to do”, recalls Joe Bondy-Denomy, a microbiologist at the University of California, San Francisco. As a
The 2010s brought major advancements in every aspect of the life sciences and ushered in an era of collaboration and multidisciplinary approaches. The Scientist spoke
Artificial intelligence tackles life science Look under the hood of many of this year’s headline-making discoveries in biology and you’ll find machine learning, a tool
A central aspect of aging research concerns the question of when individuality in lifespan arises1. Here we show that a transient increase in reactive oxygen
Every man, woman, and mouse partakes in a different amount of voluntary physical activity. Some willingly run miles a day with no destination in mind,
Trophoblasts, cells present during development in the fetus and placenta that also circulate in a pregnant woman’s bloodstream, could potentially be used for noninvasive prenatal
Earlier this year, the US Food and Drug Administration approved the most expensive drug ever to hit the market, a gene therapy for spinal muscular
Cell therapies to treat cardiac damage have been moving through clinical trials, with mixed results. Often, stem cells are taken from a patient’s bone marrow
Grajevis Bakatunkanda’s mother knew the signs: when her son lost interest in dinner, that meant the pain was on its way. It would strike, like
Our genetic material is littered with parasitic DNA sequences, known as transposons, which promote their own propagation and transmission, rather than their host’s1. Their movements
The first patients in each of two early-stage clinical trials testing CRISPR-based treatments for inherited blood disorders have been symptom free for several months with
From Alaska down to the Baja Peninsula, the rocky tide pools of North America’s West Coast are separated by hundreds of kilometers of sandy beaches.
Created by ePubSystems. Contact Us for similar site for your university or institute.