High caloric intake induces inflammation
The consumption of high-calorie diets has become prevalent in industrialized nations and is associated with increased body mass, inflammation, and resulting pathologies. What are the
The consumption of high-calorie diets has become prevalent in industrialized nations and is associated with increased body mass, inflammation, and resulting pathologies. What are the
Abstract Genetically predisposed CTLA4 insufficiency in humans is associated with gastric cancer development, which is paradoxical to the prototypical role of CTLA4 in suppressing antitumor
Highlights •LXR agonism reduces immunosuppressive MDSC levels in mice and cancer patients •LXR transcriptional target ApoE impairs MDSC survival •LXR-induced MDSC depletion enhances activation of
An international team of researchers has found that the immune system reacts to typically high-calorie, Western-style diets in much the same way that it does
The thymus, an organ in the lymphatic system, plays a critical role in immune function, producing the T cells essential to the immune response. While
Several haematological malignancies, including multiple myeloma (MM) and acute myeloid leukaemia (AML), have well-defined precursor states that precede the development of overt cancer. MM is
Antimicrobial resistance (AMR) and the associated morbidity and mortality due to bacterial pathogens have been increasing globally to alarming levels. The World Health Organization (WHO)
Highlights •Inflammation is associated with changes in the chromatin landscape of MPN cells •NF-κB is constitutively active in MPNs and drives MPN-associated inflammation •JQ1 shows
Highlights IDO1 and TDO2 catalyze the commitment and rate-limiting step of the KYN metabolic pathway that produces the endogenous AhR agonist KYN. Activation of AhR
In this issue of JEM, Chheda et al. (https://doi.org/10.1084/jem.20171046) report that a conserved hotspot mutation associated with an aggressive form of brain cancer generates an
Tuberculosis is no longer on the LAM Lipoarabinomannan (LAM) is a component of the cell wall shed by Mycobacterium tuberculosis, the bacteria responsible for tuberculosis,
T cell non-Hodgkin lymphomas are a heterogeneous group of highly aggressive malignancies with poor clinical outcomes1. T cell lymphomas originate from peripheral T cells and
One of the major challenges of the current Zika virus (ZIKV) epidemic is to prevent congenital foetal abnormalities, including microcephaly, following ZIKV infection of pregnant
More than 500 organizations from 67 countries have now endorsed a campaign promoting awareness that virally suppressed HIV-positive people cannot sexually transmit HIV. Launched in
Engineering an immune cell to recognize and kill a cancer cell is the key to chimeric antigen receptor (CAR) T-cell therapy, but modified immune cells
Exciting progress in the field of cancer immunotherapy has renewed the urgency of the need for basic studies of immunoregulation in both adaptive cell lineages
Researchers report promising results in a Phase 1 trial testing a new cell therapy using chimeric antigen receptor (CAR) T-cell technology on patients suffering from
In 2015, gastroenterologist Edwin Liu set to work on a clinical and genetic data set that had been growing for more than 20 years. The
Researchers have a new way to understand the much-studied Berlin patient’s unexpected cure from HIV and improve outcomes of stem cell transplants for patients with
Researchers have a new way to understand the much-studied Berlin patient’s unexpected cure from HIV and improve outcomes of stem cell transplants for patients with
In the past week, public health officials in Madagascar have reported 230 new cases of plague and 17 deaths from the bacterial disease, bringing the
Numerous microorganisms, including bacteria, colonize the intestine where they play important roles in maintaining homeostasis. However, commensal bacteria with pathogenic potential, such as Helicobacter hepaticus,
Some malaria researchers say their worst fears are coming true. A malaria parasite resistant to resistant to a first-line artemisinin combination therapy has rapidly made
One mutation in the Zika virus is responsible for catastrophic consequences in its hosts. A sequence change resulting in one amino acid substitution can convert
A patient’s own cells can be engineered to combat cancer. Called a “living drug”, the cells hunt and destroy cancer cells, sometimes adding years to
Created by ePubSystems. Contact Us for similar site for your university or institute.