Abstract Satellites are mobile genetic elements that are dependent upon the replication machinery of their helper viruses. Bacteriophages have provided many examples of satellite nucleic
Abstract Whether CD8+ T lymphocytes control human immunodeficiency virus infection by cytopathic or non-cytopathic mechanisms is not fully understood. Multiple studies highlighted non-cytopathic effects, but one
Highlights Summary Background Patients with severe uncontrolled asthma represent a distinct endotype with persistent airway inflammation and remodeling that is refractory to corticosteroid treatment. CD4+ TH2
Abstract Coronavirus spike proteins mediate receptor binding and membrane fusion, making them prime targets for neutralizing antibodies. In the cases of severe acute respiratory syndrome
Editor’s summary Healthcare-associated infections are a leading threat to patient safety during hospital stays, and strategies to prevent such infections are lacking. Here, Yan et al.
Abstract Development of immunocompetent T cells in the thymus is required for effective defence against all types of pathogens, including viruses, bacteria and fungi. To
Editor’s summary Dendritic cells (DCs) migrate over long distances to shuttle antigen from peripheral tissues to lymph nodes. Immune cell trafficking is mediated by chemotactic
Abstract In atherosclerosis, some regulatory T (Treg) cells become exTreg cells. We crossed inducible Treg and exTreg cell lineage-tracker mice (FoxP3eGFP−Cre-ERT2ROSA26CAG-fl-stop-fl-tdTomato) to atherosclerosis-prone Apoe−/− mice, sorted Treg cells and exTreg cells and
Abstract Malaria is caused by Plasmodium species transmitted by Anopheles mosquitoes. Following a mosquito bite, Plasmodium sporozoites migrate from skin to liver, where extensive replication occurs, emerging later as merozoites that
Abstract HIV-1 infection depends on the integration of viral DNA into host chromatin. Integration is mediated by the viral enzyme integrase and is blocked by
Abstract The physiological functions of mast cells remain largely an enigma. In the context of barrier damage, mast cells are integrated in type 2 immunity
Abstract Viruses in built environments (BEs) raise public health concerns, yet they are generally less studied than bacteria. To better understand viral dynamics in BEs,
Abstract In August 2022, a novel henipavirus (HNV) named Langya virus (LayV) was isolated from patients with severe pneumonic disease in China. This virus is
Abstract Despite no apparent defects in T cell priming and recruitment to tumors, a large subset of T cell rich tumors fail to respond to
Editor’s summary Psoriasis is a chronic inflammatory skin disease that is often accompanied by systemic complications. Using spatial transcriptomics (ST), Castillo and Sidhu et al. examined
Highlights Summary PSGL-1 (P-selectin glycoprotein-1) is a T cell-intrinsic checkpoint regulator of exhaustion with an unknown mechanism of action. Here, we show that PSGL-1 acts upstream
Abstract Bacterial bloodstream infections (BSIs) resulting in late-onset sepsis affect up to half of extremely preterm infants and have substantial morbidity and mortality. Bacterial species
Significance The ability of cells to sense and respond to mechanical forces underlies many important processes in biology, from morphogenesis to cancer metastasis. However, whether
Significance ACh-releasing choline acetyltransferase (ChAT)+ T cells promote vasodilation and regulate blood pressure in mice, but human ChAT+ T cells and the molecular mechanisms by which ChAT-expression is regulated remain
Highlights Summary HIV-1 encounters the hierarchically organized host chromatin to stably integrate and persist in anatomically distinct latent reservoirs. The contribution of genome organization in
Abstract Tumors use multiple mechanisms to actively exclude immune cells involved in antitumor immunity. Strategies to overcome these exclusion signals remain limited due to an
Dendritic cells save the day Dendritic cells are a key part of the immune system and are critical for antitumor immunity because they help to
Catching out cap snatching Some virus families hijack part of their hosts’ RNA to enable their own replication in a process called cap snatching. Before
Highlights Summary Local environmental factors influence CD8+ T cell priming in lymph nodes (LNs). Here, we sought to understand how factors unique to the tumor-draining mediastinal LN
Significance Macrophages are innate immune cells that use pattern recognition receptors such as the toll-like receptors (TLRs) to sense danger. Individual TLRs detect danger in
Created by ePubSystems. Contact Us for similar site for your university or institute.