Abstract Almost all brain cells contain cilia, antennae-like microtubule-based organelles. Yet, the significance of cilia, once considered vestigial organelles, in the higher-order brain functions is
Abstract Designer receptors exclusively activated by designer drugs (DREADDs) represent a powerful chemogenetic technology for the remote control of neuronal activity and cellular signalling1,2,3,4. The
Abstract Parkinson’s disease (PD) may start in the gut and spread to the brain. To investigate the role of gut microbiome, we conducted a large-scale
Significance Although symptomatic medications are available, many temporal lobe epilepsy (TLE) patients remain unresponsive to treatment and new drug targets are needed. Connexin-based gap junctions
Highlights Summary Regulation of pre-mRNA splicing and polyadenylation plays a profound role in neurons by diversifying the proteome and modulating gene expression in response to
Highlights Early hypotheses of claustrum function were fueled by neuroanatomical data and yielded suggestions that the claustrum is involved in processes ranging from salience detection
Abstract Amyloid self-assembly is linked to numerous devastating cell-degenerative diseases. However, designing inhibitors of this pathogenic process remains a major challenge. Cross-interactions between amyloid-β peptide
Significance Can one brain hemisphere perform the functions of the typical two hemispheres? Typically, in adults, there are right and left hemispheric biases for face
A new study by researchers from Case Western Reserve University may help explain the sex-based difference in the incidence rate of Alzheimer’s disease (AD) that makes women
Abstract Oxidative genome damage is an unavoidable consequence of cellular metabolism. It arises at gene regulatory elements by epigenetic demethylation during transcriptional activation1,2. Here we
Abstract We study the collapse and expansion of a cavitation bubble in a deformable porous medium. We develop a continuum-scale model that couples compressible fluid
Abstract Microglia are emerging as key drivers of neurological diseases. However, we lack a systematic understanding of the underlying mechanisms. Here, we present a screening
Abstract Advances in 3D neuronal cultures, such as brain spheroids and organoids, are allowing unprecedented in vitro access to some of the molecular, cellular and
Abstract We describe in vivo follow-up PET imaging and postmortem findings from an autosomal dominant Alzheimer’s disease (ADAD) PSEN1 E280A carrier who was also homozygous for the APOE3 Christchurch
Highlights •VNS paired with success enhances skilled motor learning in healthy animals •Enhanced motor performance is due to accelerated consolidation of an expert motor plan
Halting astrocytes at the GAT3 Uncontrolled inflammation in the brain after an injury has been shown to contribute to increased seizure risk and cognitive impairments.
A growing body of literature ties the gut microbiome to symptoms of depression in a seemingly circular relationship where each affects the other. However, many of the studies
Highlights •NPC proliferation defects are common in idiopathic and 16p11.2 CNV-deletion ASD •All macrocephalic I-ASD and 16pDel individuals have hyperproliferative NPCs •NPC proliferative responses to
Abstract The ability of immune-modulating biologics to prevent and reverse pathology has transformed recent clinical practice. Full utility in the neuroinflammation space, however, requires identification
bstract Genetic variants in YWHAZ contribute to psychiatric disorders such as autism spectrum disorder and schizophrenia, and have been related to an impaired neurodevelopment in humans and
Highlights •We made a light-weight 2-photon miniscope for calcium imaging in freely moving mice •Stable high-quality imaging was observed during a wide spectrum of behaviors
Targeting microglia with niacin Microglia have been shown to contribute in Alzheimer’s disease (AD) pathophysiology. However, the role of these cells remains to be completely
Abstract Progressive degeneration of dopaminergic (DA) neurons in the substantia nigra is a hallmark of Parkinson’s disease (PD). Dysregulation of developmental transcription factors is implicated
Highlights •PolyP is enriched in human and mouse ALS/FTD astrocytes in vitro and in vivo •Excessive polyP released by ALS/FTD astrocytes is toxic to primary MNs •In vitro studies indicate that polyP
Significance Multiple sclerosis (MS) is the most prevalent autoimmune disease of the central nervous system (CNS), leading to irreversible deficits in young adults. Its pathophysiology
Created by ePubSystems. Contact Us for similar site for your university or institute.