Highlights • Gata3, Eomes, Tfap2c, Myc, and Esrrb convert fibroblasts into iPSCs, iTSCs, and iXENs • Esrrb, but not other pluripotency genes, can shift the
A person with HIV seems to be free of the virus after receiving a stem-cell transplant that replaced their white blood cells with HIV-resistant versions.
The Japanese government’s health ministry has given the go-ahead for a trial of human induced pluripotent stem cells to treat spinal cord injury, Reuters reports
Among stem cell policy changes instituted since U.S. President Barack Obama took office, the National Institutes of Health (NIH) made a linkurl:controversial move;http://www.the-scientist.com/blog/display/57274/ to not
Among stem cell policy changes instituted since U.S. President Barack Obama took office, the National Institutes of Health (NIH) made a linkurl:controversial move;http://www.the-scientist.com/blog/display/57274/ to not
Scientists have for the first time grown functioning human blood vessel organoids from stem cells in the lab. Their study, published on Wednesday (January 16)
Neurons derived from the skin cells of people with and without autism spectrum disorder exhibit different patterns of growth and development, according to a study
Over the past five years, various studies have shown that mouse and human stem cells can spontaneously organize in a dish into 3D structures that
Breast tissue undergoes a remarkable transformation to allow for breastfeeding—and the process reverses after weaning. Lipid-filled fat cells essentially disappear to make room for milk
For the past few decades, it has been possible to directly manipulate an organism’s genes early in development, to generate, for example, mice that harbour
The sleep disorder narcolepsy is linked to immune-system genes and is caused by the loss of neurons that express the protein hypocretin. Hypocretin-targeting immune cells
Contrary to previous assumptions, it seems the cells that line blood vessels are derived from more than one source. In addition to their known developmental
Pluripotent cells have been used to probe developmental pathways that are involved in genetic diseases and oncogenic events. To find new therapies that would target
Researchers have used three types of stem cells to create a mouse embryo in a dish, according to research published in Nature Cell Biology yesterday
Injecting human cardiac muscle cells into monkeys that suffered heart attacks helped the animals’ damaged hearts pump blood better, researchers report July 2 in Nature
Summary Restoration of insulin independence and normoglycemia has been the overarching goal in diabetes research and therapy. While whole-organ and islet transplantation have become gold-standard
Abstract Most of the hematopoietic stem cells (HSCs) within the bone marrow (BM) show quiescent state with a low mitochondrial membrane potential (ΔΨm). In contrast,
The pancreas is made from two distinct components: the exocrine pancreas, a reservoir of digestive enzymes, and the endocrine islets, the source of the vital
Stem cell-based clinical interventions are increasingly advancing through preclinical testing and approaching clinical trials. The complexity and diversity of these approaches, and the confusion created
A pharmaceutical company based in Osaka, Japan, opened a regenerative medicine center yesterday (March 22) that will produce cells derived from induced pluripotent stem (iPS)
With their pluripotency and ability to self-renew, some cancer cells have been likened to stem cells. Now, researchers show that the similarities between the cells
Multipotent stromal cells have long been a hot topic in medical research. Scientists at the University of Bonn have now found a way to specifically
Highlights •39 patient-derived pancreas adenocarcinomas (PDACs) form a tumor organoid library •PDAC segregates into 3 subtypes with distinct dependency on Wnt niche signals •Cancer-associated fibroblasts
A new way of inducing pluripotency has been demonstrated by scientists based at the Gladstone Institutes. Rather than fuss with the usual transcription factors or
Highlights •Somatic cell nuclear transfer (SCNT) using fetal fibroblasts yielded two live monkeys •Epigenetic modulators promoted development and pregnancy rate of SCNT embryos •SCNT using
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