Highlights •Generation of hiPS cell-derived 3D spheroids resembling the hindbrain/spinal cord •Synaptically connected corticofugal projections in fused cortico-spinal assembloids •Stimulation of cortical neurons controls skeletal
Abstract Neural stem cells (NSCs) generate neurons throughout life in the mammalian hippocampus. However, the potential for long-term self-renewal of individual NSCs within the adult
Highlights •Scalable process for differentiating hiPSC-microcarrier aggregates into RBCs •Erythroid differentiation potential of multiple hiPSC lines was evaluated •hiPSC RBCs and adult RBCs revealed minor
Highlights •A phenotypic screening assay based on human RPE and POS was established •Screen identifies ramoplanin as an inducer of POS phagocytosis in hESC-RPE •Ramoplanin
Significance Transfer of sperm-producing stem cells isolated from a donor male into testes of a recipient male has important applications for preserving germplasm and as
The first single-cell analysis of the human ovarian cortex revealed six main types of cells, but none of the oogonial stem cells that other researchers
Injections of stem cells—either a patient’s own or from a donor—into the hearts of people with cardiac conditions has been shown in some cases to
Scientists are experimenting with ways to selectively target the body’s blood-making cells for destruction. Early studies in animals and people suggest that the approach could
Injections of stem cells—either a patient’s own or from a donor—into the hearts of people with cardiac conditions has been shown in some cases to
Since 2006, when Shinya Yamanaka, now the director of the Center for iPS Cell Research and Application at Kyoto University, discovered a method that could
Pelizaeus-Merzbacher disease is a genetic malady that leaves neurons without their myelin coating. This deficit has devastating consequences for the boys—it’s X-linked—who have it. “These
Neuroscientist Gregor Pilz of the University of Zurich has watched stem cells turn into neurons in the brains of young, living mice—a feat that not
Definitive haematopoiesis in the fetal liver supports self-renewal and differentiation of haematopoietic stem cells and multipotent progenitors (HSC/MPPs) but remains poorly defined in humans. Here,
A single type of mouse stem cell can generate a structure in culture capable of self-organizing to generate both embryonic cells and those that are
Tucked away in Tokyo’s trendiest fashion district — two floors above a pricey French patisserie, and alongside nail salons and jewellers — the clinicians at
A woman in Japan with a corneal disease has become the first person in the world to receive a corneal transplant made from induced pluripotent
Cortical organoids—three-dimensional bundles of neurons and glia grown in a dish from induced pluripotent stem cells—look a lot like tiny brains. And while the gene
An international team of researchers has created embryos containing both human and monkey cells, the Spanish newspaper El País reported July 31. The controversial project
Last Friday (July 26), the National Institutes of Health announced new restrictions on human fetal tissue research for scientists applying for grants using the material
In a healthy adult, tissue-specific stem cells replenish damaged tissue and sustain plasticity (the addition of new cells) in organs. In two regions of the
Using human embryonic stem cells (ES cells), researchers have generated models of early human embryos in the lab that are more complex than any previous
An “off-the-shelf” cell therapy derived from induced pluripotent stem cells (iPSCs) has entered clinical trials in the United States. Other companies are following suit, harnessing
Researchers have developed lab-generated lymph node–like organoids that, when transplanted into mice in place of lymph nodes that have been removed, drain fluid and connect
Researchers have managed to grow large numbers of blood-forming stem cells in the lab using a surprisingly simple ingredient found in glue. And when injected
In mice whose sense of smell has been disabled, a squirt of stem cells into the nose can restore olfaction, researchers report today (May 30)
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