Highlights •Skin organoids can be generated from mPSCs under defined conditions •Skin organoids are composed of self-assembled epidermal and dermal layers •Skin organoids produce hair
Last May, to much fanfare, an international group of researchers published two papers describing a new in vitro system that had maintained human embryos in
The promise of cell-based therapy is limited by the challenge of generating large enough numbers of the correct type of cells. But a strategy called
Stemming attacks on the pancreas In type 1 diabetes, autoreactive CD4 T cells attack and kill pancreatic β cells, disrupting insulin production. Many approaches have
Thanks to an international team of scientists and doctors, a seven-year-old Syrian refugee who lost most of his outer skin to a life-threatening genetic disease
The restoration of dentine lost in deep caries lesions in teeth is a routine and common treatment that involves the use of inorganic cements based
A signature event for organoids Human cancer genomes harbor cryptic mutational signatures that represent the cumulative effects of DNA damage and defects in DNA repair
Scientists have used the gene-editing CRISPR-Cas9 system to suppress the gene encoding the protein OCT4 in experiments with human embryos. According to the results, published
Induced pluripotent stem cells (iPS cells) are a promising source for a cell-based therapy to treat Parkinson’s disease (PD), in which midbrain dopaminergic neurons progressively
By her 50th birthday, Els van der Heijden felt sicker than ever. Born with the hereditary disorder cystic fibrosis (CF), she had managed to work
Paul Knoepfler is an unlikely watchdog for the therapeutic stem cell industry. His University of California, Davis, lab mostly uses stem cells to study cancer-causing
Engineering human livers is a lofty goal. Human liver cells, hepatocytes, are particularly difficult to grow in the laboratory as they lose liver functions quickly
Texas last week signaled its defiance of the federal government over unproven stem cell therapies, which are widely offered in the state for conditions including
Two teams of scientists have generated blood stem cells by reprogramming either human or mouse cells. In both cases, these hematopoietic stem cells successfully produced
Abstract Macrophages have diverse functions in immunity as well as development and homeostasis. Here we identify a function for these cells in long distance communication
Highlights •Stem cell lineage infidelity occurs transiently in wounds and persists in cancer •Wounds and cancer converge on lineage infidelity irrespective of stem cell origin
Two years ago, researchers at Johns Hopkins University School of Medicine analyzed data on 31 cancer types, finding that the number of stem cell divisions
Japanese researchers reported this week that the first trial of induced pluripotent stem (iPS) cells in a human has proved safe and effective in halting
Neural stem cells (NSCs) are ideal recruits for search-and-destroy missions in the brain. They have an innate ability to home in on cancer cells, and
Islet transplantation is an established therapy for diabetes. We have previously shown that rat pancreata can be created from rat pluripotent stem cells (PSCs) in
How to maintain hematopoietic stem cells Hematopoiesis provides the body with a continuous supply of blood cells (see the Perspective by Sommerkamp and Trumpp). Taya
The female germ line undergoes a unique sequence of differentiation processes that confers totipotency to the egg<a id="ref-link-2" title="Surani, M. A., Hayashi, K. & Hajkova,
Scientists have for this first time reprogrammed murine embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) into fully functional oocytes in the laboratory.
Cardiac muscle cells derived from induced pluripotent stem cells (iPSCs) and injected into monkeys helped the animals’ hearts recover from a heart attack, according to
Donor stem cell–derived retinal epithelial cells whose immune proteins correspond to those of a recipient are tolerated following transplant into monkeys’ eyes, according to a
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