Improving organ allocation in transplant A major challenge in lung transplantation is the need for ABO blood group matching. To address this challenge, Wang et al. used
Abstract The function of the lung is closely coupled to its structural anatomy, which varies greatly across vertebrates. Although architecturally simple, a complex pattern of
A US$2-million, 8-year attempt to replicate influential preclinical cancer research papers has released its final — and disquieting — results. Fewer than half of the
Highlights •In a retrospective study, ex vivo drug testing predicts GBM patient survival •Testing is based on detecting subtle changes in single-cell mass •Predictive power of functional testing
Abstract Vaccination is an essential public health measure for infectious disease prevention. The exposure of the immune system to vaccine formulations with the appropriate kinetics
Abstract Focused ultrasound can deliver energy safely and non-invasively into tissues at depths of centimetres. Here we show that the genetics and cellular functions of
Abstract Naive human pluripotent stem cells (hPSCs) can be used to generate mature human cells of all three germ layers in mouse–human chimeric embryos. Here,
Abstract In early mitosis, the duplicated chromosomes are held together by the ring-shaped cohesin complex1. Separation of chromosomes during anaphase is triggered by separase—a large
Plastic is notoriously hard to break down, but a study by researchers in Austria has shown that bacteria from a cow’s rumen—one of the four
Abstract Glycosaminoglycans (GAGs) are important biopolymers that differ in the sequence of saccharide units and in post polymerisation alterations at various positions, making these complex
Abstract Despite many significant advances in 3D cell printing for skin, a disease model displaying the pathological processes present in the native skin has not
Lipid nanoparticles (LNPs) are the most clinically advanced delivery system for RNA-based drugs but have predominantly been investigated for intravenous and intramuscular administration. Subcutaneous administration
Highlights •A human stem cell-derived organoid model of widespread and compact myelination •Recapitulated impaired paranode formation in patient-derived cultures •Pharmacological modulation of oligodendrocyte morphology and
Regeneration without scarring Wounds in adult mammals typically heal by forming fibrotic scars. Mascharak et al. found that a specific population of skin fibroblasts (Engrailed-1 lineage–negative fibroblasts) activate
Abstract Cathepsin B (catB) is a lysosomal cysteine protease expressed in several cells and organs, where it plays a role in protein degradation and turnover.
Purpose To develop a safe and noninvasive in vivo assay of hepatic propionate oxidative capacity. Methods A modified 1-13C-propionate breath test was administered to 57
Abstract Uterine sensitization–associated gene-1 (USAG-1) deficiency leads to enhanced bone morphogenetic protein (BMP) signaling, leading to supernumerary teeth formation. Furthermore, antibodies interfering with binding of USAG-1
Abstract RNAi therapy has undergone two stages of development, direct injection of synthetic siRNAs and delivery with artificial vehicles or conjugated ligands; both have not
Highlights •A reverse genetics approach determines genes required for normal cell division •Normal cell division requires genes of known and unknown function •JCVI-syn3A offers a
Abstract Malaria is caused by unicellular Plasmodium parasites. Plasmodium relies on diverse microtubule cytoskeletal structures for its reproduction, multiplication, and dissemination. Due to the small size of this parasite,
Key Points SCD patients have elevated cell-free mitochondrial DNA (cf-mtDNA) that can be sourced to abnormal retention of mitochondria in RBCs The cf-mtDNA is disproportionately
Organoids regenerate human bile ducts Bile ducts carry bile from the liver and gall bladder to the small intestine, where it aids digestion. Cholangiocytes are
Highlights •Transmission of PCOS traits in mice occurs via an altered DNA methylation landscape •Metabolic- and inflammatory-related pathways are dysregulated in models of PCOS •Common
Significance Deconstruction of recalcitrant polymers, such as cellulose or chitin, is accomplished in nature by synergistic enzyme cocktails that evolved over millions of years. In
It was a Friday afternoon in March 2013 when Andy Geall got the call. Three people in China had just become infected with a new
Created by ePubSystems. Contact Us for similar site for your university or institute.