Abstract Aberrant activation of Ras/Raf/mitogen-activated protein kinase (MAPK) signaling is frequently linked to metastatic prostate cancer (PCa); therefore, the characterization of modulators of this pathway
Abstract Targeted protein degradation is an emerging strategy for the elimination of classically undruggable proteins. Here, to expand the landscape of targetable substrates, we designed
Abstract Proton transfer between the DNA bases can lead to mutagenic Guanine-Cytosine tautomers. Over the past several decades, a heated debate has emerged over the
Abstract Lysine L-lactylation [K(L-la)] is a newly discovered histone mark stimulated under conditions of high glycolysis, such as the Warburg effect. K(L-la) is associated with
The mRNAs expressed by SARS-CoV-2 can pass as human mRNAs without too much difficulty. All the viral mRNAs have to do is modify the cap
A compound found in the waxy coating of coffee beans may work in synergy with caffeine to protect against Parkinson’s disease (PD), according to research
Ribonuclease P (RNase P) recognizes precursor transfer RNA (pre-tRNA) and processes it to generate mature tRNAs that are used for assembling proteins. Unlike almost all
A team of cancer researchers has identified a pair of enzymes that they say could serve as therapeutic targets whose inhibition would block the growth
Years after Elizabeth Blackburn, Ph.D. won the Nobel Prize for her seminal work on the molecular nature of telomeres and co-discovery of the ribonucleoprotein enzyme
The context Researchers have long reported that green tea drinkers have better health outcomes, but why that is has been unclear. To get to the
The finding that phosphoinositide-3-OH kinase δ restrains the antitumour immune response by promoting the action of suppressive immune cells may broaden the applicability of drugs
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